Mechanism of Factor XII-associated Hereditary Angioedema (A11)

• Subject Area: Public Health, Healthcare Research, Social and Occupational Medicine
• Term: from 2014 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 125440785

The project focuses on the plasma protease factor XII (FXII) and analyzes mechanisms and therapies of the rare inherited swelling disease Hereditary Angioedema type III that has been associated with mutations in FXII. In the next funding period, the project will study FXII activation-mechanisms and regulation of FXII protease activity. An experimental gene-therapy for Hereditary Angioedema will be developed. Understanding FXII regulation will offer new therapeutic strategies for Hereditary angioedema and potentially other FXII-driven disease states.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 877: Proteolysis as a Regulatory Event in Pathophysiology
• Applicant Institution: Christian-Albrechts-Universität zu Kiel
• Project Head: Professor Dr. Thomas Renné, since 1/2018