Understanding the complex cellular dynamics of Multiple Sclerosis pathophysiology: In vivo imaging of immune cells, CNS endogenous cells and the demyelinating axon in Multiple Sclerosis and its animal model

• Applicant: Privatdozent Dr. Volker Siffrin
• Subject Area: Molecular and Cellular Neurology and Neuropathology ; Immunology ; Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2014 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 263020259

• Final Report Year: 2023

No abstract available

Publications

• Flow cytometric analysis of T cell/monocyte ratio in clinically isolated syndrome identifies patients at risk of rapid disease progression. Multiple Sclerosis Journal, Vol. 22. 2016, Issue 4, pp. 483–493.
  Nemecek, Andrea; Zimmermann, Hilga; Rübenthaler, Johannes; Fleischer, Vinzenz; Paterka, Magdalena; Luessi, Felix; Müller-Forell, Wibke; Zipp, Frauke & Siffrin, Volker
  
• Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis. Journal of Autoimmunity, Vol. 76. 2017, pp. 108-114.
  Paterka, Magdalena; Voss, Jan Oliver; Werr, Johannes; Reuter, Eva; Franck, Sophia; Leuenberger, Tina; Herz, Josephine; Radbruch, Helena; Bopp, Tobias; Siffrin, Volker & Zipp, Frauke
  
• CCR7 on CD4+ T Cells Plays a Crucial Role in the Induction of Experimental Autoimmune Encephalomyelitis. Journal of Immunology, Vol. 200, 2018, Issue 8, pp. 2554–2562.
  Belikan, Patrick; Bühler, Ulrike; Wolf, Christina; Pramanik, Gautam K.; Gollan, René; Zipp, Frauke & Siffrin, Volker
  
• Comparison of RNA isolation procedures for analysis of adult murine brain and spinal cord astrocytes. Journal of Neuroscience Methods, Vol. 333. 2020, 108545.
  Rosiewicz, Kamil Sebastian; Crowley, Tadhg; Saher, Gesine; Kerkering, Janis; Alisch, Marlen & Siffrin, Volker
  
• Identification of the gliogenic state of human neural stem cells to optimize in vitro astrocyte differentiation. Journal of Neuroscience Methods, Vol. 361. 2021, 109284.
  Alisch, Marlen; Kerkering, Janis; Crowley, Tadhg; Rosiewicz, Kamil; Paul, Friedemann & Siffrin, Volker
  
• HIF prolyl hydroxylase 2/3 deletion disrupts astrocytic integrity and exacerbates neuroinflammation. GLIA, Vol. 71. 2023, Issue 8, pp. 2024-2044.
  Rosiewicz, Kamil Sebastian; Muinjonov, Bakhrom; Kunz, Séverine; Radbruch, Helena; Chen, Jessy; Jüttner, René; Kerkering, Janis; Ucar, Julia; Crowley, Tadhg; Wielockx, Ben; Paul, Friedemann; Alisch, Marlen & Siffrin, Volker