Understanding the complex cellular dynamics of Multiple Sclerosis pathophysiology: In vivo imaging of immune cells, CNS endogenous cells and the demyelinating axon in Multiple Sclerosis and its animal model

• Applicant: Privatdozent Dr. Volker Siffrin
• Subject Area: Molecular and Cellular Neurology and Neuropathology ; Immunology ; Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2014 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 263020259

• Final Report Year: 2023

Final Report Abstract

No abstract available

Publications

• Flow cytometric analysis of T cell/monocyte ratio in clinically isolated syndrome identifies patients at risk of rapid disease progression. Multiple Sclerosis Journal, Vol. 22. 2016, Issue 4, pp. 483–493.
  Nemecek, A., Zimmermann, H., Rübenthaler, J., Fleischer, V., Paterka, M., Luessi, F., Müller-Forell, W., Zipp, F., Siffrin, V.
  (See online at https://doi.org/10.1177/1352458515593821)
• Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis. Journal of Autoimmunity, Vol. 76. 2017, pp. 108-114.
  Paterka, M., Voss, J.O., Werr, J., Reuter, E., Franck, S., Leuenberger, T., Herz, J., Radbruch, H., Bopp, T., Siffrin, V., Zipp, F.
  (See online at https://doi.org/10.1016/j.jaut.2016.09.008)
• CCR7 on CD4+ T Cells Plays a Crucial Role in the Induction of Experimental Autoimmune Encephalomyelitis. Journal of Immunology, Vol. 200, 2018, Issue 8, pp. 2554–2562.
  Belikan, P., Bühler, U., Wolf, C., Pramanik, G.K., Gollan, R., Zipp, F., Siffrin, V.
  (See online at https://doi.org/10.4049/jimmunol.1701419)
• Comparison of RNA isolation procedures for analysis of adult murine brain and spinal cord astrocytes. Journal of Neuroscience Methods, Vol. 333. 2020, 108545.
  Rosiewicz, K.S., Crowley, T., Saher, G., Kerkering, J., Alisch, M., Siffrin, V.
  (See online at https://doi.org/10.1016/j.jneumeth.2019.108545)
• Identification of the gliogenic state of human neural stem cells to optimize in vitro astrocyte differentiation. Journal of Neuroscience Methods, Vol. 361. 2021, 109284.
  Alisch, M., Kerkering, J., Crowley, T., Rosiewicz, K., Paul, F., Siffrin, V.
  (See online at https://doi.org/10.1016/j.jneumeth.2021.109284)
• HIF prolyl hydroxylase 2/3 deletion disrupts astrocytic integrity and exacerbates neuroinflammation. GLIA, Vol. 71. 2023, Issue 8, pp. 2024-2044.
  Rosiewicz, K.S., Muinjonov, B., Kunz, S., Radbruch, H., Chen, J., Jüttner, R., Kerkering, J., Ucar, J., Crowley, T., Wielockx, B., Paul, F., Alisch, M., Siffrin, V.
  (See online at https://doi.org/10.1002/glia.24380)