Die Regulation des Ceramid/Sphingosin-1-Phosphat-Gleichgewichts durch Ceramidasen und Sphingosinkinasen in Nierenzellen und deren Bedeutung für Entzündungs- und Firbroseprozesse

• Antragsteller: Professor Dr. Josef M. Pfeilschifter
• Mitantragstellerin: Professorin Dr. Andrea Huwiler (†)
• Fachliche Zuordnung: Pharmakologie
• Förderung: Förderung von 2006 bis 2014
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 26333961

• Erstellungsjahr: 2014

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (2008) Sphingolipids take the center stage: Sphingosine 1-phosphate and its receptors as new drug targets, Biochem Pharmacol 75: 1893-1900
  Huwiler, Andrea & Pfeilschifter, Josef
  
• (2008) Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells. Biochim Biophys Res Commun 368: 1020-1025
  Schwalm, Stephanie; Döll, Frauke; Römer, Isolde; Bubnova, Svetlana; Pfeilschifter, Josef & Huwiler, Andrea
  
• (2009) Involvement of the ABC-transporter ABCC1 and the sphingosine-1-phosphate receptor subtype S1P3 in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone. J Mol Med 87: 645-657
  Nieuwenhuis, Barbara; Lüth, Anja; Chun, Jerold; Huwiler, Andrea; Pfeilschifter, Josef; Schäfer-Korting, Monika & Kleuser, Burkhard
  
• (2009) The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. Biochem Biophys Res Commun, 389: 251-256
  Czech, Bozena; Pfeilschifter, Waltraud; Mazaheri-Omrani, Niloufar; Strobel, Marc André; Kahles, Timo; Neumann-Haefelin, Tobias; Rami, Abdelhaq; Huwiler, Andrea & Pfeilschifter, Josef
  
• Transforming growth factor-β2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-β2 by impeding CTGF expression. Kidney Int 76: 857-867
  Ren, Shuyu; Babelova, Andrea; Moreth, Kristin; Xin, Cuiyan; Eberhardt, Wolfgang; Doller, Anke; Pavenstädt, Hermann; Schaefer, Liliana; Pfeilschifter, Josef & Huwiler, Andrea
  
• (2010) A novel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation. Cell Physiol Biochem, 26: 97-104
  Ren, Shuyu; Xin, Cuiyan; Pfeilschifter, Josef & Huwiler, Andrea
  
• (2010) Glucocorticoids protect renal mesangial cells from apoptosis by increasing cellular sphingosine-1-phosphate levels. Kidney Int 77: 870-879
  Förster, Ankathrin; Emmler, Tanja; Schwalm, Stephanie; Ebadi, Mahsa; Heringdorf, Dagmar Meyer zu; Nieuwenhuis, Barbara; Kleuser, Burkhardt; Huwiler, Andrea & Pfeilschifter, Josef
  
• (2010) Nitric oxide upregulates sphingosine kinase-1 expression and activity in the human endothelial cell line EA.hy 926 and critically regulates endothelial tube formation. Br J Pharmacol 160: 1641-1651
  Schwalm, Stephanie; Pfeilschifter, Josef & Huwiler, Andrea
  
• 20100311843A1: Compositions and methods for the treatment of glomerulonephritis
  B. Johansen, A. Huwiler
  
• (2011) A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders. PLOS One, 6: e22436
  Huwiler, Andrea; Bourquin, Florence; Kotelevets, Nataliya; Pastukhov, Oleksandr; Capitani, Guido; Grütter, Markus G. & Zangemeister-Wittke, Uwe
  
• (2011) Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia. Biochem Biophys Res Commun. 413: 212-217
  Pfeilschifter, Waltraud; Czech-Zechmeister, Bożena; Sujak, Marian; Mirceska, Ana; Koch, Alexander; Rami, Abdelhaq; Steinmetz, Helmuth; Foerch, Christian; Huwiler, Andrea & Pfeilschifter, Josef
  
• EP2505589 A1: Novel sphingolipid heterocyclic compounds as modulators of sphingolipid signaling and uses thereof
  Stark, H., Zivkovic, A., Pfeilschifter, J., and Huwiler, A
  
• PCT/EP2011/071446: Use of prokaryotic sphingosine-1-phosphate lyases and of sphingosine-1-phosphate lyases lacking a transmembrane domain for treating hyperproliferative and other diseases
  Zangemeister-Wittke U., Huwiler, A., Bourquin, F., and Grütter, M
  
• (2013) Dual role of sphingosine kinase 1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. Oncogene
  Albinet, V.; Bats, M.-L.; Huwiler, A.; Rochaix, P.; Chevreau, C.; Ségui, B.; Levade, T. & Andrieu-Abadie, N.
  
• (2013) Sphingosine-1-phosphate: a Janus-faced mediator of fibrotic diseases. Biochim Biophys Acta - Mol Cell Biol Lipids 1831: 239-250
  Schwalm, Stephanie; Pfeilschifter, Josef & Huwiler, Andrea
  
• (2013) Targeting the sphingosine kinase/ sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases. Basic and Clinical Pharmacology and Toxicology
  Schwalm, Stephanie; Pfeilschifter, Josef & Huwiler, Andrea
  
• (2008) Mesangial cells derived from sphingosine kinase 1 and 2 deficient mice display opposite behaviour to apoptotic stimuli. Biol Chem, 389: 1399-1407
  Schwalm, Stephanie; Timcheva, Tankica Maneva; Filipenko, Iuliia; Ebadi, Mahsa; Hofmann, Lotte P.; Zangemeister-Wittke, Uwe; Pfeilschifter, Josef & Huwiler, Andrea