Dickkopf-1 als phänotypische Determinante ossärer Metastasen beim Mammakarzinom

• Antragstellerinnen / Antragsteller: Dr. Tilmann Rachner; Professorin Dr. Martina Rauner
• Fachliche Zuordnung: Hämatologie, Onkologie
• Förderung: Förderung von 2014 bis 2018
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 179902948

• Erstellungsjahr: 2018

Zusammenfassung der Projektergebnisse

In summary, we were able to show that DKK-1 expression acts as a negative prognostic predictor in ER negative breast cancer and blocking DKK-1 reduces tumor burden in mice. However, the metastastic process is influenced by DKK-1 at different levels and while some aspects are unaltered or inhibited, other aspects like migration are increased by DKK-1 inhibition. Further studies are warranted to elucidate these effects in more detail.

Projektbezogene Publikationen (Auswahl)

• P38 regulates the Wnt inhibitor Dickkopf-1 in breast cancer. Biochem Biophys Res Commun. 2015;466:728-32
  Rachner TD, Göbel A, Browne A, Hötzel J, Rauner M, Hofbauer LC
  
• Potentiated suppression of Dickkopf-1 in breast cancer by combined administration of the mevalonate pathway inhibitors zoledronic acid and statins. Breast Cancer Res Treat. 2015;154:623-31
  Göbel A, Browne AJ, Thiele S, Rauner M, Hofbauer LC, Rachner TD
  
• p38 MAPK regulates the Wnt inhibitor Dickkopf-1 in osteotropic prostate cancer cells. Cell Death Dis. 2016;7:e2119
  Browne AJ, Göbel A, Thiele S, Hofbauer LC, Rauner M, Rachner TD
  
• Adjuvant tamoxifen but not aromatase inhibitor therapy decreases serum levels of the Wnt inhibitor dickkopf-1 while not affecting sclerostin in breast cancer patients. Breast Cancer Res Treat. 2017;164:737-43
  Göbel A, Kuhlmann JD, Link T, Wimberger P, Browne AJ, Rauner M, Hofbauer LC, Rachner TD
  
• Concurrent antitumor and bone-protective effects of everolimus in osteotropic breast cancer. Breast Cancer Res. 2017;19:92
  Browne AJ, Kubasch ML, Göbel A, Hadji P, Chen D, Rauner M, Stölzel F, Hofbauer LC, Rachner TD