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Projekt Druckansicht

Funktionale Bedeutung der Transmembranhelices und des Turrets für das Gating von Kaliumkanälen

Fachliche Zuordnung Biochemie und Biophysik der Pflanzen
Förderung Förderung von 2014 bis 2018
Projektkennung Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 265445268
 
Erstellungsjahr 2019

Zusammenfassung der Projektergebnisse

The project has produced interesting results regarding: a) A so far unknown mechanism for a cytosolic gate in K+ channels that particularly stands out because of its unusual simplicity. b) A novel concept of regulation of gating by voltage. In the absence of a dedicated voltage-sensor domain, the extracellular turret is apparently able to confer voltagesensitivity. c) The possibility to determined site-specific ion occupation in the pore from electrophysiological data, which enabled the distinction of several candidate permeation models from MD simulations and the identification of a distinct sensor binding site in the selectivity filter. Additionally, the project generated incentive for new projects regarding the role of inner-helical hydrogen bonds for channel gating and the mechanisms of selectivity filter gating.

Projektbezogene Publikationen (Auswahl)

 
 

Zusatzinformationen

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