Functional analysis of the polycystin-1-signaling module (B02)

• Subject Area: Nephrology
• Term: from 2015 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 246781735

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenetic hereditary diseases. Mutations in the genes PKD1 and PKD2 cause ADPKD, but the pathogenic mechanisms remain largely unclear. PKD1 encodes for Polycystin-1, a membrane protein that has been implicated in multiple signal transduction pathways. The goal of this project is to investigate the role of Polycystin-1 in signal transduction using biochemical and genetic methods. These experiments may help to identify novel therapeutic targets for ADPKD.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1140: Kidney Disease - from Genes to Mechanisms (KIDGEM)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Michael Köttgen