Identification of novel kinase targets up- and downstream of mTOR by Kinase Correlation Profiling (C02)

• Subject Area: Dermatology
• Term: from 2015 to 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 246781735

Autosomal dominant polycystic kidney disease is the most common inherited kidney disease and the fourth most single cause of end-stage renal disease. Major treatment strategies aim to (a) reduce cAMP levels, (b) inhibit mTOR and cell proliferation, and (c) reduce fluid secretion. Several kinase inhibitors are currently being tested in preclinical or clinical trials. We will use mass spectrometry-based phoshoproteomics to identify target molecules of inhibited kinases. These targets will be tested for their relevance in new causal, molecular therapeutic strategies.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1140: Kidney Disease - from Genes to Mechanisms (KIDGEM)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Jörn Dengjel