Hydroaminoalkylation - Imine Addition from the Amine Oxidation Level

• Applicant: Dr. Jana Franke
• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: from 2014 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 268007563

The research proposal describes the development of a new catalytic hydroaminoalkylation. Classical carbonyl additions often involve a stoichiometric amount of metal-organic species or LEWIS-acids, (e.g. grignard addition, aldol reactions) producing a stoichiometric amount of metallic byproducts, making scale-up difficult. Krische et al. developed a new catalytic C-C bond forming transfer hydrogenation method that circumvents most of these problems and opens up new opportunities for synthesis. The transfer hydrogenation reaction involves a hydrogen exchange between alcohols and unsaturated reactants, generating carbonyl-organometal pairs that combine to form carbonyl addition products.This new pattern of reactivity gives access to a lot of potentially new redox-triggered C-C bond forming reactions. In the proposed funding period, this method shall be applied to C-C couplings of amines.

• DFG Programme: Research Fellowships
• International Connection: USA
• Host: Professor Dr. Michael J. Krische