Role of ABCB5+ MSCs in niche homeostasis and repair after trauma (C05)

• Subject Area: Dermatology ; Cell Biology
• Term: since 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 251293561

We found that MSCs sense and shape their neighborhood at different trauma sites with accelerated tissue repair. Unexpectedly, combined TXT and skin trauma led to accelerated wound healing of the skin. Thus, the overarching hypothesis is that in vivo priming of MSCs in their skin niches results in improved healing. This is due to a sustained epigenetic memory of the priming event which upon wounding unleashes regenerative signaling events faster. Therefore, we explore whether 1) combined trauma (TXT, skin) primes MSCs and distinct fibroblast lineages with improved skin wound healing, 2) trauma of other organs (brain, bone) enforces an adaptive skin response and enhances MSC functionality; and 3) priming of resident skin MSCs with S100A8/9 or laser treatment enforces a subsequent regenerative wound healing.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1149: Danger Response, Disturbance Factors and Regenerative Potential after Acute Trauma
• Applicant Institution: Universität Ulm
• Project Head: Professorin Dr. Karin Scharffetter-Kochanek