Effect of phosphorylation on the archaellum regulatory protein network (P24*)

• Subject Area: Metabolism, Biochemistry and Genetics of Microorganisms
• Term: from 2015 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 26068018

Archaea use the archaellum, a motility structure that is assembled via a type IV pili mechanism, to swim. Expression of the archaellum is highly regulated and reversible protein phosphorylation of the membrane bound one component regulators ArnR and ArnR1 plays a major role in the modulation of the archaellum regulatory signaling protein network. We want to understand how phosphorylation alters the interactions in the archaellum regulatory network using biochemical, structural and in vivo approaches.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 746: Functional Specificity by Coupling and Modification of Proteins
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professorin Dr. Sonja Verena Albers