Mitochondrial morphology regulation by dynamic Bcl-2 protein complexes (P26*)

• Subject Area: Biochemistry
• Term: from 2015 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 26068018

Stress-induced mitochondrial damage is confined by fusion and fission evershifting mitochondria from fragmented vesicles to hyperfused networks. Swift and reversible changes of mitochondrial morphology and clearance indicate dynamic control processes, but how mitochondrial quality control is coordinated, remains unknown. The proposed project will explore mitochondrial morphology and clearance control by Bcl-2 proteins using stabilized Bcl-2 protein conformations and quantitative confocal microscopy techniques. We aim to establish a new concept of coupling reversible conformational changes of Bcl-2 proteins to mitochondrial dynamics regulation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 746: Functional Specificity by Coupling and Modification of Proteins
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Frank Edlich