Kinasen in der Regulation von Transportprozessen der Zellmembran

• Antragsteller: Professor Dr. Florian Lang
• Fachliche Zuordnung: Anatomie und Physiologie
• Förderung: Förderung von 2006 bis 2010
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 27316334

• Erstellungsjahr: 2010

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Blunted DOCA/high salt induced albuminuria and renal tubulointerstitial damage in gene-targeted mice lacking SGKl. J Mol Med 2006;84:737- 746
  Artunc F, Amann K, Nasir O, Friedrich B, Sandulache D, Jahovic N, Risler T, Vallon V, Wulff P, Kuhl D, Lang F
  
• Blunted hypertensive effect of combined fructose and high-salt diet in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase SGKl. Am J Physiol Regul Integr Comp Physiol 2006;290:R935-R944
  Huang DY, Boini KM, Friedrich B, Metzger M, Just L, Osswald H, Wulff P, Kuhl D, Vallon V, Lang F
  
• Enhanced expression of serum and glucocorticoid-inducible kinase-1 in kidneys of L-NAME-treated rats. Kidney Blood Press Res 2006;29:94-99
  Feng Y, Wang Y, Xiong J, Liu Z, Yard B, Lang F
  
• Impaired intestinal and renal glucose transport in PDK-1 hypomorphic mice. Am J Physiol Regul Integr Comp Physiol 2006;291 :R1533-R1538
  Artunc F, Rexhepaj R, Volkl H, Grahammer F, Remy C, Sandulache D, Nasir O, Wagner CA, Alessi DR, Lang F
  
• Impaired intestinal NHE3 activity in the PDKI hypomorphic mouse. Am J Physiol Gastrointest Liver Physiol 2006;291:G868-G876
  Sandu C, Artunc F, Palmada M, Rexhepaj R, Grahammer F, Hussain A, Yun C, Alessi DR, Lang F
  
• Intestinal function of gene-targeted mice lacking serum- and glucocorticoid-inducible kinase 1. Am J Physiol Gastrointest Liver Physiol 2006;290:G1114-Gl 123
  Grahammer F, Henke G, Sandu C, Rexhepaj R, Hussain A, Friedrich B, Risler T, Metzger M, Just L, Skutella T, Wulff P, Kuhl D, Lang F
  
• Reduced intestinal and renal amino acid transport in PDKI hypomorphic mice. FASEB J 2006;20:2214-2222
  Rexhepaj R, Grahammer F, Volkl H, Remy C, Wagner CA, Sandulache D, Artunc F, Henke G, Nammi S, Capasso G, Alessi DR, Lang F
  
• Renal Ca2+ handling in sgkl knockout mice. Pflugers Arch 2006;452:444-452
  Sandulache D, Grahammer F, Artunc F, Henke G, Hussain A, Nasir O, Mack A, Friedrich B, Vallon V, Wulff P, Kuhl D, Palmada M, Lang F
  
• Resistance of mice lacking the serumand glucocorticoid-inducible kinase SGKl against salt-sensitive hypertension induced by a high-fat diet. Am J Physiol Renal Physiol 2006;291 :F1264-F1273
  Huang DY, Boini KM, Osswald H, Friedrich B, Artunc F, Ullrich S, Rajamanickam J, Palmada M, Wulff P, Kuhl D, Vallon V, Lang F
  
• Serum- and glucocorticoid-inducible kinase 1 mediates salt sensitivity of glucose tolerance. Diabetes 2006;55:2059-2066
  Boini KM, Hennige AM, Huang DY, Friedrich B, Palmada M, Boehmer C, Grahammer F, Artunc F, Ullrich S, Avram D, Osswald H, Wulff P, Kuhl D, Vallon V, Haring HU, Lang F
  
• SGKl is not required for regulation of colonic ENaC activity. Pflugers Arch 2006;453:97- 105
  Rexhepaj R, Artunc F, Grahammer F, Nasir O, Sandu C, Friedrich B, Kuhl D, Lang F
  
• SGKl kinase upregulates GLUTI activity and plasma membrane expression. Diabetes 2006;55:421-427
  Palmada M, Boehmer C, Akel A, Rajamanickam J, Jeyaraj S, Keller K, Lang F
  
• Role ofthe serum and glucocorticoid inducible kinase SGKl in glucocorticoid stimulation of gastric acid secretion. Pflugers Arch 2007;455;493-503
  Sandu C, Artunc F, Grahammer F, Rotte A, Boini KM, Friedrich B, Sandulache D, Metzger M, Just L, Mack A, Skutella T, Rexhepaj R, Risler T, Wulff P, Kuhl D, Lang F
  
• Lack of the serum and glucocorticoid-inducible kinase SGKl attenuates the volume retention after treatment with the PPARgamma agonist pioglitazone. Pflugers Arch 2008;456:425-436
  Artunc F, Sandulache D, Nasir O, Boini KM, Friedrich B, Beier N, Dicks E, Potzsch S, Klingel K, Amann K, Blazer-Yost BL, Scholz W, Risler T, Kuhl D, Lang F
  
• Role of matemal glucocorticoid inducible kinase SGKl in fetal programming of blood pressure in response to prenatal diet. Am J Physiol Regul Integr Comp Physiol 2008;294:R2008-R2013
  Rexhepaj R, Boini KM, Huang DY, Amann K, Artunc F, Wang K, Brosens J J, Kuhl D, Lang F
  
• Role of serum- and glucocorticoid-inducible kinase SGKl in glucocorticoid reguiation of renal electrolyte excretion and blood pressure. Kidney Blood Press Res 2008;31:280-289
  Boini KM, Nammi S, Grahammer F, Osswald H, Kuhl D, Lang F
  
• Akt2 and SGK3 are both determinants of postnatal hair follicle development. FASEB J 2009;23:3193-3202
  Mauro TM, McCormick JA, Wang J, Boini KM, Ray L, Monks B, Bimbaum MJ, Lang F, Pearce D
  
• SGKl dependence of insulin induced hypokalemia. Pflugers Arch 2009;457:955-961
  Boini KM, Graf D, Kuhl D, Haussinger D, Lang F
  
• SGKl-sensitive renal tubular glucose reabsorption in diabetes. Am J Physiol Renal Physiol 2009;296:F859-F866
  Ackermann TF, Boini KM, Volkl H, Bhandaru M, Bareiss PM, Just L, Vallon V, Amann K, Kuhl D, Feng Y, Hammes HP, Lang F
  
• Stimulation of electrogenic intestinal dipeptide transport by the glucocorticoid dexamethasone. Pflugers Arch 2009;459:191-202
  Rexhepaj R, Rotte A, Kempe DS, Sopjani M, Poller M, Gehring EM, Bhandaru M, Grüner I, Mack AF, Rubio-Aliaga I, Nassl AM, Daniel H, Kuhl D, Lang F