GRK 750:  Vascular Injury in Heart and Kidney: Pathogenesis and Diagnostics

• Subject Area: Medicine
• Term: from 2001 to 2004
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 273381

The aim of the program is a better understanding of vascular injury mechanisms and of the interaction between the vasculature and the specific functional units of the heart and the kidney. Specifically, the various projects study the role of vascular structures for cardiac development, disease mechanisms of hypertrophic cardiomyopathy, altered cell-cell and cell-matrix interactions and oxidative stress as injury mechanisms, non-invasive diagnosis of arterial lesions and angiogenesis, therapeutic use of ultrasound, measurement and modification of endothelial function in patients and gene therapy for acute respiratory distress syndrome, or chimeric antibodies for the prevention of transplant rejection. It is designed for graduated natural scientists, selected advanced medical students, and for "Ärzte im Praktikum (AIP)". The research training group 750 is characterized by a strongly interdisciplinary approach to clinical research, and covers a broad range from molecular biology to modern diagnostic and therapeutic aspects of cardiovascular and renal diseases.

• DFG Programme: Research Training Groups
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Spokesperson: Professorin Dr. Margarete Goppelt-Strübe
• Participating Researchers: Professor Dr. Stephan Achenbach; Professorin Dr. Kerstin Amann; Dr. Michael Bauer; Professor Dr. Werner G. Daniel; Professor Dr. Jörg Dötsch; Professor Dr. Frank Arnold Flachskampf; Dr. Christoph Garlichs; Professorin Dr. Margarete Goppelt-Strübe; Professor Dr. Rupert Hallmann; Professorin Dr. Andrea Hartner; Professor Dr. Karl Friedrich Hilgers; Professor Dr. Torsten Kuwert; Professor Dr. Wolfgang Rascher; Dr. Thomas Rau; Professor Dr. Roland E. Schmieder; Professor Dr. Detlef Schuppan; Professorin Dr. Lydia Sorokin; Professor Dr. Roland Veelken; Professor Dr. Michael Weyand; Professor Dr. Wolfram-Hubertus Zimmermann; Professor Dr. Oliver Zolk