Functional relevance of the Rho signaling inhibitor Myosin 9B and downstream cytoskeletal proteins for cutaneous dendritic cell populations (B01)

• Subject Area: Dermatology
• Term: from 2015 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 246807620

This project investigates the relevance of cytoskeletal components for cutaneous DC functions. In particular, the functional roles of the evolutionarily conserved leukocyte-specific motor protein Myo9B and the downstream cytoskeletal effector molecules Cofilin (governs F-actin turnover) and Fascin-1 (bundles F-actin, specifically expressed in DC) will be elucidated by using genetically modified DC. The course of distinct cutaneous disease models (leishmaniasis, psoriasis, hapten- and protein-specific contact dermatitis and tolerance induction) will be assessed using mice deficient for Fascin-1 or for Myo9B in DC.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 156: The skin as sensor and effector orchestrating local and systemic immunity
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Co-Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Privatdozent Dr. Matthias Bros; Professor Dr. Stephan Grabbe