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Toxic or beneficial? Selenoneine in human selenium metabolism

Subject Area Food Chemistry
Term from 2015 to 2020
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 276311500
 
Final Report Year 2021

Final Report Abstract

Overall, the complementary expertise of the analytical chemists in Graz and the toxicologists in Potsdam led to the isolation of selenoneine and the elucidation of its possible transport mechanisms, metabolic changes and modes of action in comparison to other naturally occurring small selenium species. The in vitro transfer studies applied in this project provide evidence that selenoneine efficiently transfers across the intestinal barrier. In contrast, selenoneine is likely to have a slow transfer rate to the brain and seems not to be metabolised by the brain endothelial cells. Our studies in cultured human cells and in C.elegans indicate that selenoneine is unlikely to be involved into the Se metabolic cycle. At the same time, sulfur to Se exchange in the erhothioneine structure led to a substantial increase in the radical scavenging activity, which raises the question of the potential role of selenoneine as a highly effective dietary antioxidant.

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