Multizentrische, randomisierte, kontrollierte Studie zum Vergleich des Gewichtsverlusts mit einem endoskopischen Dünndarmbypass versus Magenballon versus einer Scheinintervention

• Antragsteller: Professor Dr. Albrecht Hoffmeister
• Fachliche Zuordnung: Gastroenterologie ; Allgemein- und Viszeralchirurgie
• Förderung: Förderung von 2016 bis 2021
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 276689665

• Erstellungsjahr: 2022

Zusammenfassung der Projektergebnisse

The WET trial proved through its excellent recruitment rate, high completeness of data and short-term results to be a well-designed and carried out trial. The loss of CE mark was unforeseeable and the efforts made to continue with the trial despite this setback were considerable. Despite the lack of power caused by the early trial stop, our data strongly suggest that IB and DJBL lead to comparable weight loss while implanted, which is superior to a sham procedure. However, these procedures fail to achieve effective weight loss 12 months after explantation. These results need to be interpreted with caution due to the trial’s early termination.

Projektbezogene Publikationen (Auswahl)

• Design of the Weight-loss Endoscopy Trial (WET): a multi-center, randomized, controlled trial comparing weight loss in endoscopically implanted duodenal-jejunal bypass liners vs. intragastric balloons vs. a sham procedure; BMC Gastroenterol 2018 Jul 18;18(1):118
  Marcus Hollenbach, Christiane Prettin, Felix Gundling, Wolfgang Schepp, Jochen Seufert, Jürgen Stein, Thomas Rösch, Jens Aberle, Jürgen Feisthammel, David Petroff, Albrecht Hoffmeister
  (Siehe online unter https://doi.org/10.1186/s12876-018-0838-3)