Harnessing monocyte and dendritic cell dependent pathways of IVIg activity to enhance resolution of inflammation (A07)

• Subject Area: Immunology ; Dermatology
• Term: from 2015 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 261193037

The central aim of project A07 is to understand the molecular and cellular pathways responsible for IVIg induced resolution of inflammation. The experiments proposed during the third funding period build on the observations of the second funding period demonstrating that two immune cell subsets, Ly6Chigh classical monocytes and type 2 conventional dendritic cells (cDC2), are critically involved in mediating resolution of inflammation. In detail, we plan to decipher how IVIg reprograms monocytes and cDC2 in different organ environments and to transfer the results to other in vivo models of inflammation to gain a holistic view on how IVIg triggers resolution of inflammation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1181: Checkpoints for Resolution of Inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Heads: Professorin Dr. Diana Dudziak; Professor Dr. Falk Nimmerjahn