Role of IDO in resolution of inflammatory autoimmune responses by CD83-induced regulatory mechanisms in arthritis (B03)

• Subject Area: Immunology
• Term: from 2015 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 261193037

Project B03 (Steinkasserer) will extend its work regarding the role of CD83-induced indoleamine-2,3-dioxygenase- (IDO) metabolism in resolution of inflammation. In the first funding period CD83 was identified as a key factor that not only stimulates the biosynthesis of IDO but also triggers resolution of inflammation. In the second phase of CRC1181, project B03 will follow the concept that CD83 activation modulates amino acid and short chain fatty acid metabolism and thereby facilitates resolution of inflammation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1181: Checkpoints for Resolution of Inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Head: Professor Dr. Alexander Steinkasserer