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Characteristics and consequences of subcellular calcium signalling in spinal neurons and glia in chronic inflammatory and neuropathic pain (A05)

Subject Area Epidemiology and Medical Biometry/Statistics
Term from 2015 to 2019
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 255156212
 
Activity-induced intracellular Ca2+ signaling plays an invaluable role in processes that control persistent adaptations within the CNS. Indeed, Ca2+ signaling in spinal cord neurons, astrocytes, and microglia is strongly implicated in maladaptive pain plasticity. In this study, we will investigate the spatiotemporal features of synaptic activity-triggered Ca2+ signals in distinct subcellular compartments within spinal neuroglial networks, determine whether and how they are altered in chronic pain, and investigate how nuclear Ca2+ signals contribute to the development and maintenance of structural plasticity and nociceptive hypersensitivity in persistent pain models.
DFG Programme Collaborative Research Centres
 
 

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