Totalsynthese des Macrolid-Antibiotikums Dolabelid A
Final Report Abstract
The efforts towards the enantioselective synthesis of the C18-C25 fragment of (-)-Lasonolide A are presented in this postdoctoral research report. The developed concept required the formation of a cyclization precursor bearing a cyclic enol ether and a cyclic acetal. Upon ionisalion under lewis acid catalysis, the resulted oxocarbenium ion should undergo facile Prins cyclization to form the desired compound. Unfortunately the cyclization precursor is not accessible to date. More important, the concept developed in this context works with a simplified model compound satisfied. Although this model compound seems to very sensitive since it is densely functionalized, the chemistry used varies from modern transformations to robust and reliable reactions.
