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Evolutionäre und genomische Faktoren für die Entwicklung einer optimalen adaptiven Immunantwort
Antragsteller
Professor Dr. Tobias Lenz
Fachliche Zuordnung
Evolution, Anthropologie
Humangenetik
Immunologie
Humangenetik
Immunologie
Förderung
Förderung von 2016 bis 2022
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 279645989
Erstellungsjahr
2022
Zusammenfassung der Projektergebnisse
Keine Zusammenfassung vorhanden
Projektbezogene Publikationen (Auswahl)
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Ancient DNA study reveals HLA susceptibility loci for leprosy in medieval Europeans. Nature Communications 9: 1569
Krause-Kyora B, Nutsua M, Böhme L, Pierini F, Pedersen DD, Kornell S-C, Drichel D, Bonazzi M, Möbus L, Tarp P, Susat J, Bosse E, Willburger B, Schmidt AH, Sauter J, Franke A, Wittig M, Calibe A, Nothnagel M, Schreiber S, Boldsen J, Lenz TL, Nebel A
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Divergent allele advantage at human MHC genes: signatures of past and ongoing selection. Molecular Biology and Evolution 35: 2145-2158
Pierini F, Lenz TL
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Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy. Nature Medicine 25: 1715-1720
Chowell D, Krishna C, Pierini F, Makarov V, Rizvi NA, Kuo F, Riaz N, Lenz TL, Chan TA
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HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control. Proceedings of the National Academy of Sciences USA 116: 944-949
Arora J, McLaren PJ, Chaturvedi N, Carrington M, Fellay J, Lenz TL
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Advances in the evolutionary understanding of MHC polymorphism. Trends in Genetics 36: 298-311
Radwan J, Babik W, Kaufman J, Lenz TL, Winternitz J
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Genome-wide association study in severe Covid-19 with respiratory failure. New England Journal of Medicine 383:1522-1534
Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, Fernández J, Prati D, Baselli G, Asselta RA, Grimsrud MM, Milani C, Aziz FA, Kässens J, May S, Wendorff M, Wienbrandt L, Uellendahl-Werth F, Zheng T, Yi X, de Pablo R, Chercoles AG, Palom A, Garcia-Fernandez A-E, Rodriguez-Frias F, Zanella A, Bandera A, Protti A, Aghemo A, Lleo A, Biondi A, Caballero- Garralda A, Gori A, Tanck A, Nolla AC, Latiano A, Fracanzani AL, Peschuck A, Julià A, Pesenti A, Voza A, Jiménez D, Mateos B, Jimenez BN, Quereda C, Paccapelo C, Gassner C, Angelini C, Cea C, Solier A, Pestaña D, Muñiz-Diaz E, Sandoval E, Paraboschi EM, Navas E, Sánchez FG, Ceriotti F, Martinelli- Boneschi F, Peyvandi F, Blasi F, Téllez L, Blanco-Grau A, Hemmrich-Stanisak G, Grasselli G, Costantino G, Cardamone G, Foti G, Aneli S, Kurihara H,
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HLA heterozygote advantage against HIV-1 is driven by quantitative and qualitative differences in HLA allele-specific peptide presentation. Molecular Biology and Evolution 37: 639-650
Arora J, Pierini F, McLaren PJ, Carrington M, Fellay J, Lenz TL
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Targeted analysis of polymorphic loci from low-coverage shotgun sequence data allows accurate genotyping of HLA genes in historical human populations. Scientific Reports 10:7339
Pierini F, Nutsua M, Böhme L, Özer O, Bonczarowska J, Susat J, Franke A, Nebel A, Krause-Kyora B, Lenz TL
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Mapping the human genetic architecture of COVID-19. Nature 600: 472–477
COVID-19 Host Genetics Initiative
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Unique pathogen peptidomes facilitate pathogen-specific selection and specialization of MHC alleles. Molecular Biology and Evolution 38: 4376-4387
Özer O, Lenz TL