Evolutionäre und genomische Faktoren für die Entwicklung einer optimalen adaptiven Immunantwort

• Antragsteller: Professor Dr. Tobias Lenz
• Fachliche Zuordnung: Evolution, Anthropologie ; Humangenetik ; Immunologie
• Förderung: Förderung von 2016 bis 2022
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 279645989

• Erstellungsjahr: 2022

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Ancient DNA study reveals HLA susceptibility loci for leprosy in medieval Europeans. Nature Communications 9: 1569
  Krause-Kyora, Ben; Nutsua, Marcel; Boehme, Lisa; Pierini, Federica; Pedersen, Dorthe Dangvard; Kornell, Sabin-Christin; Drichel, Dmitriy; Bonazzi, Marion; Möbus, Lena; Tarp, Peter; Susat, Julian; Bosse, Esther; Willburger, Beatrix; Schmidt, Alexander H.; Sauter, Jürgen; Franke, Andre; Wittig, Michael; Caliebe, Amke; Nothnagel, Michael; ... & Nebel, Almut
  
• Divergent allele advantage at human MHC genes: signatures of past and ongoing selection. Molecular Biology and Evolution 35: 2145-2158
  Pierini, Federica & Lenz, Tobias L.
  
• Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy. Nature Medicine 25: 1715-1720
  Chowell, Diego; Krishna, Chirag; Pierini, Federica; Makarov, Vladimir; Rizvi, Naiyer A.; Kuo, Fengshen; Morris, Luc G. T.; Riaz, Nadeem; Lenz, Tobias L. & Chan, Timothy A.
  
• HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control. Proceedings of the National Academy of Sciences USA 116: 944-949
  Arora, Jatin; McLaren, Paul J.; Chaturvedi, Nimisha; Carrington, Mary; Fellay, Jacques & Lenz, Tobias L.
  
• HLA heterozygote advantage against HIV-1 is driven by quantitative and qualitative differences in HLA allele-specific peptide presentation. Molecular Biology and Evolution 37: 639-650
  Arora, Jatin; Pierini, Federica; Mclaren, Paul J.; Carrington, Mary; Fellay, Jacques & Lenz, Tobias L.
  
• Advances in the evolutionary understanding of MHC polymorphism. Trends in Genetics 36: 298-311
  Radwan, Jacek; Babik, Wiesław; Kaufman, Jim; Lenz, Tobias L. & Winternitz, Jamie
  
• Genome-wide association study in severe Covid-19 with respiratory failure. New England Journal of Medicine 383:1522-1534
  Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, Fernández J, Prati D, Baselli G, Asselta RA, Grimsrud MM, Milani C, Aziz FA, Kässens J, May S, Wendorff M, Wienbrandt L, Uellendahl-Werth F, Zheng T, Yi X, de Pablo R, Chercoles AG, Palom A, Garcia-Fernandez A-E, Rodriguez-Frias F, Zanella A, Bandera A, Protti A, Aghemo A, Lleo A, Biondi A, Caballero- Garralda A, Gori A, Tanck A, Nolla AC, Latiano A, Fracanzani AL, Peschuck A, Julià A, Pesenti A, Voza A, Jiménez D, Mateos B, Jimenez BN, Quereda C, Paccapelo C, Gassner C, Angelini C, Cea C, Solier A, Pestaña D, Muñiz-Diaz E, Sandoval E, Paraboschi EM, Navas E, Sánchez FG, Ceriotti F, Martinelli- Boneschi F, Peyvandi F, Blasi F, Téllez L, Blanco-Grau A, Hemmrich-Stanisak G, Grasselli G, Costantino G, Cardamone G, Foti G, Aneli S, Kurihara H,
  
• Targeted analysis of polymorphic loci from low-coverage shotgun sequence data allows accurate genotyping of HLA genes in historical human populations. Scientific Reports 10:7339
  Pierini, Federica; Nutsua, Marcel; Böhme, Lisa; Özer, Onur; Bonczarowska, Joanna; Susat, Julian; Franke, Andre; Nebel, Almut; Krause-Kyora, Ben & Lenz, Tobias L.
  
• Mapping the human genetic architecture of COVID-19. Nature 600: 472–477
  Niemi, Mari E. K.; Karjalainen, Juha; Liao, Rachel G.; Neale, Benjamin M.; Daly, Mark; Ganna, Andrea; Pathak, Gita A.; Andrews, Shea J.; Kanai, Masahiro; Veerapen, Kumar; Fernandez-Cadenas, Israel; Schulte, Eva C.; Striano, Pasquale; Marttila, Minttu; Minica, Camelia; Marouli, Eirini; Karim, Mohd Anisul; Wendt, Frank R.; Savage, Jeanne; ... & Donohue, Chloe
  
• Unique pathogen peptidomes facilitate pathogen-specific selection and specialization of MHC alleles. Molecular Biology and Evolution 38: 4376-4387
  Özer, Onur & Lenz, Tobias L.