Evolutionary genomics of an optimal adaptive immune response

• Applicant: Professor Dr. Tobias Lenz
• Subject Area: Evolution, Anthropology ; Human Genetics ; Immunology
• Term: from 2016 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 279645989

• Final Report Year: 2022

Final Report Abstract

No abstract available

Publications

• Ancient DNA study reveals HLA susceptibility loci for leprosy in medieval Europeans. Nature Communications 9: 1569
  Krause-Kyora B, Nutsua M, Böhme L, Pierini F, Pedersen DD, Kornell S-C, Drichel D, Bonazzi M, Möbus L, Tarp P, Susat J, Bosse E, Willburger B, Schmidt AH, Sauter J, Franke A, Wittig M, Calibe A, Nothnagel M, Schreiber S, Boldsen J, Lenz TL, Nebel A
  (See online at https://doi.org/10.1038/s41467-018-03857-x)
• Divergent allele advantage at human MHC genes: signatures of past and ongoing selection. Molecular Biology and Evolution 35: 2145-2158
  Pierini F, Lenz TL
  (See online at https://doi.org/10.1093/molbev/msy116)
• Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy. Nature Medicine 25: 1715-1720
  Chowell D, Krishna C, Pierini F, Makarov V, Rizvi NA, Kuo F, Riaz N, Lenz TL, Chan TA
  (See online at https://doi.org/10.1038/s41591-019-0639-4)
• HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control. Proceedings of the National Academy of Sciences USA 116: 944-949
  Arora J, McLaren PJ, Chaturvedi N, Carrington M, Fellay J, Lenz TL
  (See online at https://doi.org/10.1073/pnas.1812548116)
• Advances in the evolutionary understanding of MHC polymorphism. Trends in Genetics 36: 298-311
  Radwan J, Babik W, Kaufman J, Lenz TL, Winternitz J
  (See online at https://doi.org/10.1016/j.tig.2020.01.008)
• Genome-wide association study in severe Covid-19 with respiratory failure. New England Journal of Medicine 383:1522-1534
  Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, Fernández J, Prati D, Baselli G, Asselta RA, Grimsrud MM, Milani C, Aziz FA, Kässens J, May S, Wendorff M, Wienbrandt L, Uellendahl-Werth F, Zheng T, Yi X, de Pablo R, Chercoles AG, Palom A, Garcia-Fernandez A-E, Rodriguez-Frias F, Zanella A, Bandera A, Protti A, Aghemo A, Lleo A, Biondi A, Caballero- Garralda A, Gori A, Tanck A, Nolla AC, Latiano A, Fracanzani AL, Peschuck A, Julià A, Pesenti A, Voza A, Jiménez D, Mateos B, Jimenez BN, Quereda C, Paccapelo C, Gassner C, Angelini C, Cea C, Solier A, Pestaña D, Muñiz-Diaz E, Sandoval E, Paraboschi EM, Navas E, Sánchez FG, Ceriotti F, Martinelli- Boneschi F, Peyvandi F, Blasi F, Téllez L, Blanco-Grau A, Hemmrich-Stanisak G, Grasselli G, Costantino G, Cardamone G, Foti G, Aneli S, Kurihara H,
  (See online at https://doi.org/10.1056/NEJMoa2020283)
• HLA heterozygote advantage against HIV-1 is driven by quantitative and qualitative differences in HLA allele-specific peptide presentation. Molecular Biology and Evolution 37: 639-650
  Arora J, Pierini F, McLaren PJ, Carrington M, Fellay J, Lenz TL
  (See online at https://doi.org/10.1093/molbev/msz249)
• Targeted analysis of polymorphic loci from low-coverage shotgun sequence data allows accurate genotyping of HLA genes in historical human populations. Scientific Reports 10:7339
  Pierini F, Nutsua M, Böhme L, Özer O, Bonczarowska J, Susat J, Franke A, Nebel A, Krause-Kyora B, Lenz TL
  (See online at https://doi.org/10.1038/s41598-020-64312-w)
• Mapping the human genetic architecture of COVID-19. Nature 600: 472–477
  COVID-19 Host Genetics Initiative
  (See online at https://doi.org/10.1038/s41586-021-03767-x)
• Unique pathogen peptidomes facilitate pathogen-specific selection and specialization of MHC alleles. Molecular Biology and Evolution 38: 4376-4387
  Özer O, Lenz TL
  (See online at https://doi.org/10.1093/molbev/msab176)