Transkriptionelle Regulation der funktionellen Spezialisierung von Monozyten Populationen während Gesundheit und Krankheit

• Antragsteller: Professor Dr. Andreas Schlitzer
• Fachliche Zuordnung: Immunologie
• Förderung: Förderung von 2016 bis 2022
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 282795005

• Erstellungsjahr: 2023

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Tissue‐resident macrophages — how to humanize our knowledge. Immunology & Cell Biology, 95(2), 173-177.
  Schlitzer, Andreas & Schultze, Joachim L.
  
• Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2. Immunity, 47(6), 1051-1066.e12.
  Sander, Jil; Schmidt, Susanne V.; Cirovic, Branko; McGovern, Naomi; Papantonopoulou, Olympia; Hardt, Anna-Lena; Aschenbrenner, Anna C.; Kreer, Christoph; Quast, Thomas; Xu, Alexander M.; Schmidleithner, Lisa M.; Theis, Heidi; Thi, Huong Lan Do; Sumatoh, Hermi Rizal Bin; Lauterbach, Mario A.R.; Schulte-Schrepping, Jonas; Günther, Patrick; Xue, Jia; Baßler, Kevin ... & Schultze, Joachim L.
  
• The Stimulation of Macrophages with TLR Ligands Supports Increased IL-19 Expression in Inflammatory Bowel Disease Patients and in Colitis Models. The Journal of Immunology, 199(7), 2570-2584.
  Steinert, Anna; Linas, Ioannis; Kaya, Berna; Ibrahim, Mohamed; Schlitzer, Andreas; Hruz, Petr; Radulovic, Katarina; Terracciano, Luigi; Macpherson, Andrew J & Niess, Jan Hendrik
  
• Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell, 172(1-2), 147-161.e12.
  Mitroulis, Ioannis; Ruppova, Klara; Wang, Baomei; Chen, Lan-Sun; Grzybek, Michal; Grinenko, Tatyana; Eugster, Anne; Troullinaki, Maria; Palladini, Alessandra; Kourtzelis, Ioannis; Chatzigeorgiou, Antonios; Schlitzer, Andreas; Beyer, Marc; Joosten, Leo A.B.; Isermann, Berend; Lesche, Mathias; Petzold, Andreas; Simons, Kai; Henry, Ian ... & Chavakis, Triantafyllos
  
• Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming. Cell, 172(1-2), 162-175.e14.
  Christ, Anette; Günther, Patrick; Lauterbach, Mario A.R.; Duewell, Peter; Biswas, Debjani; Pelka, Karin; Scholz, Claus J.; Oosting, Marije; Haendler, Kristian; Baßler, Kevin; Klee, Kathrin; Schulte-Schrepping, Jonas; Ulas, Thomas; Moorlag, Simone J.C.F.M.; Kumar, Vinod; Park, Min Hi; Joosten, Leo A.B.; Groh, Laszlo A.; Riksen, Niels P. ... & Latz, Eicke
  
• Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells. Cell, 178(6), 1509-1525.e19.
  Liu, Zhaoyuan; Gu, Yaqi; Chakarov, Svetoslav; Bleriot, Camille; Kwok, Immanuel; Chen, Xin; Shin, Amanda; Huang, Weijie; Dress, Regine J.; Dutertre, Charles-Antoine; Schlitzer, Andreas; Chen, Jinmiao; Ng, Lai Guan; Wang, Honglin; Liu, Zhiduo; Su, Bing & Ginhoux, Florent
  
• Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches. Science, 363(6432).
  Chakarov, Svetoslav; Lim, Hwee Ying; Tan, Leonard; Lim, Sheau Yng; See, Peter; Lum, Josephine; Zhang, Xiao-Meng; Foo, Shihui; Nakamizo, Satoshi; Duan, Kaibo; Kong, Wan Ting; Gentek, Rebecca; Balachander, Akhila; Carbajo, Daniel; Bleriot, Camille; Malleret, Benoit; Tam, John Kit Chung; Baig, Sonia; Shabeer, Muhammad ... & Ginhoux, Florent
  
• β-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: a Crucial Role for IL-32. Cell Reports, 28(10), 2659-2672.e6.
  Dos Santos, Jéssica Cristina; Barroso de Figueiredo, Ana Marina; Teodoro, Silva Muriel Vilela; Cirovic, Branko; de Bree, L. Charlotte J.; Damen, Michelle S.M.A.; Moorlag, Simone J.C.F.M.; Gomes, Rodrigo S.; Helsen, Monique M.; Oosting, Marije; Keating, Samuel T.; Schlitzer, A.; Netea, Mihai G.; Ribeiro-Dias, Fátima & Joosten, Leo A.B.
  
• BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment. Cell Host & Microbe, 28(2), 322-334.e5.
  Cirovic, Branko; de Bree, L. Charlotte J.; Groh, Laszlo; Blok, Bas A.; Chan, Joyce; van der Velden Walter, J.F.M.; Bremmers, M.E.J.; van Crevel, Reinout; Händler, Kristian; Picelli, Simone; Schulte-Schrepping, Jonas; Klee, Kathrin; Oosting, Marije; Koeken, Valerie A.C.M.; van Ingen, Jakko; Li, Yang; Benn, Christine S.; Schultze, Joachim L.; Joosten, Leo A.B. ... & Schlitzer, Andreas
  
• Defining trained immunity and its role in health and disease. Nature Reviews Immunology, 20(6), 375-388.
  Netea, Mihai G.; Domínguez-Andrés, Jorge; Barreiro, Luis B.; Chavakis, Triantafyllos; Divangahi, Maziar; Fuchs, Elaine; Joosten, Leo A. B.; van der Meer, Jos W. M.; Mhlanga, Musa M.; Mulder, Willem J. M.; Riksen, Niels P.; Schlitzer, Andreas; Schultze, Joachim L.; Stabell, Benn Christine; Sun, Joseph C.; Xavier, Ramnik J. & Latz, Eicke
  
• Nasal Pneumococcal Density Is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens. American Journal of Respiratory and Critical Care Medicine, 201(3), 335-347.
  Mitsi, Elena; Carniel, Beatriz; Reiné, Jesús; Rylance, Jamie; Zaidi, Seher; Soares-Schanoski, Alessandra; Connor, Victoria; Collins, Andrea M.; Schlitzer, Andreas; Nikolaou, Elissavet; Solórzano, Carla; Pojar, Sherin; Hill, Helen; Hyder-Wright, Angela D.; Jambo, Kondwani C.; Oggioni, Marco R.; De Ste, Croix Megan; Gordon, Stephen B.; Jochems, Simon P. & Ferreira, Daniela M.
  
• Reprogramming of bone marrow myeloid progenitor cells in patients with severe coronary artery disease. eLife, 9.
  Noz, Marlies P.; Bekkering, Siroon; Groh, Laszlo; Nielen, Tim M. J.; Lamfers, Evert J. P.; Schlitzer, Andreas; El Messaoudi, Saloua; van Royen, Niels; Huys, Erik H. J. P. G.; Preijers, Frank W. M. B.; Smeets, Esther M. M.; Aarntzen, Erik H. J. G.; Zhang, Bowen; Li, Yang; Bremmers, Manita EJ; van der Velden, Walter J. F. M.; Dolstra, Harry; Joosten, Leo A. B.; Gomes, Marc E. ... & Riksen, Niels P.
  
• Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nature Immunology, 22(1), 2-6.
  Divangahi, Maziar; Aaby, Peter; Khader, Shabaana Abdul; Barreiro, Luis B.; Bekkering, Siroon; Chavakis, Triantafyllos; van Crevel, Reinout; Curtis, Nigel; DiNardo, Andrew R.; Dominguez-Andres, Jorge; Duivenvoorden, Raphael; Fanucchi, Stephanie; Fayad, Zahi; Fuchs, Elaine; Hamon, Melanie; Jeffrey, Kate L.; Khan, Nargis; Joosten, Leo A. B.; Kaufmann, Eva ... & Netea, Mihai G.
  
• Transmission of trained immunity and heterologous resistance to infections across generations. Nature Immunology, 22(11), 1382-1390.
  Katzmarski, Natalie; Domínguez-Andrés, Jorge; Cirovic, Branko; Renieris, Georgios; Ciarlo, Eleonora; Le Roy, Didier; Lepikhov, Konstantin; Kattler, Kathrin; Gasparoni, Gilles; Händler, Kristian; Theis, Heidi; Beyer, Marc; van der Meer, Jos W. M.; Joosten, Leo A. B.; Walter, Jörn; Schultze, Joachim L.; Roger, Thierry; Giamarellos-Bourboulis, Evangelos J.; Schlitzer, Andreas & Netea, Mihai G.
  
• Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation.
  Theobald, H.; Bejarano, D.A.; Katzmarski, N.; Haub, J.; Schulte-Schrepping, J.; Yu, J.; Bassler, K.; Ćirović, B.; Osei-Sarpong, C.; Piattini, F.; Vornholz, L.; Yu, X.; Sheoran, S.; Al Jawazneh, A.; Chakarov, S.; Haendler, K; Brown, G. D.; Williams, D. L.; Bosurgi, L. ... & Schlitzer, A.