Allosteric regulation of UDP-sugar pyrophosphorylases as a means to develop new anti-parasitic treatments

• Applicant: Dr. Roman Fedorov
• Subject Area: Biochemistry ; Biophysics ; Structural Biology
• Term: from 2015 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 282955187

• Final Report Year: 2021

No abstract available

Publications

• Structural and biochemical studies of sulphotransferase 18 from Arabidopsis thaliana explain its substrate specificity and reaction mechanism. (2017) Sci. Rep. 7(1):4160
  Hirschmann, Felix; Krause, Florian; Baruch, Petra; Chizhov, Igor; Mueller, Jonathan Wolf; Manstein, Dietmar J.; Papenbrock, Jutta & Fedorov, Roman
  
• Decoding Allosteric Networks in Biocatalysts: Rational Approach to Therapies and Biotechnologies. (2018) ACS Catalysis. 8:2683- 2692
  Cramer, Johannes T.; Führing, Jana I.; Baruch, Petra; Brütting, Christian; Knölker, Hans-Joachim; Gerardy-Schahn, Rita & Fedorov, Roman
  
• Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening. (2019) Molecules, 24(5): 996
  Prakash, Ohm; Führing, Jana; Post, John; Shepherd, Sharon M.; Eadsforth, Thomas C.; Gray, David; Fedorov, Roman & Routier, Françoise H.
  
• Allosteric modulation of cardiac myosin mechanics and kinetics by the conjugated omega-7,9 trans-fat rumenic acid. (2021) J Physiol 599.15: 3639–3661
  Pertici, Irene; Taft, Manuel H.; Greve, Johannes N.; Fedorov, Roman; Caremani, Marco & Manstein, Dietmar J.