Selective autophagy of mitochondria and peroxisomes in organismic aging and development (D07 (B03))

• Subject Area: Cell Biology ; Developmental Biology
• Term: from 2016 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259130777

In this project we use the two well-established model organisms Podospora anserina and Caenorhabditis elegans to elaborate the impact of mitophagy and pexophagy on organismic aging and development. We put special emphasis on the role of membrane trafficking factors such as sorting nexins, the Rab GTPase Rab7L1/GLO-1, and the dynamin-related protein DNM1/DRP-1 for these two forms of selective autophagy.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1177: Molecular and Functional Characterization of Selective Autophagy
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Professor Dr. Stefan Eimer; Professor Dr. Heinz Dieter Osiewacz