Mechanisms and function of T cell derived cytokines in crescentic glomerulonephritis (A01)

• Subject Area: Nephrology
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 264599542

In this project, we will address the following topics: 1.) Investigation of the mechanisms and function of CD4+ T cell trafficking in crescentic GN, with a special focus on T cell retention and emigration from the kidney, using mice engineered to express the photoconvertible fluorescence protein Kaede. 2.) Analysis of the regulation and function of CD4+ T cell-subset-derived cytokines (e.g. IL-17A) in tissue homeostasis and inflammation. 3.) Decoding of the CD4+ T cell/cytokine immune signature in patients with crescentic GN (ANCA-GN) by combining single-cell and spatially resolved OMICS analyses with systems immunology techniques in a translational approach. In summary, our studies will provide a more comprehensive understanding of T cell-derived cytokine function in autoimmunity. This offers a unique opportunity to develop pathogenesis-based and personalized anti-cytokine treatment strategies in crescentic GN.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1192: Immune-Mediated Glomerular Diseases - Basic Concepts and Clinical Implications -
• Applicant Institution: Universität Hamburg
• Project Head: Professor Dr. Ulf Panzer