Die Funktion von CLEC-1 in der Haut
Parasitologie und Biologie der Erreger tropischer Infektionskrankheiten
Zusammenfassung der Projektergebnisse
In this research project I was able to fulfill all my short term goals set in the proposal: (1) I increased my scientific visibility documented by the invitation to review a scientific publication, (2) I gained knowledge in state-of-the-art technologies and increased my skill set (3) I increased my scientific network (e.g. collaboration with Dr Martin Stacey, University of Leeds on Il-36) and (4) gained intense expertise in fungal immunology. I set the basis for my own independent research in the field of dermatophytes, a research topic hardly addressed in the scientific community. In the first 6 month I had to adapt and change the focus of the whole project because of the inability to detect MelLec (Clec-1) in the quiescent skin. I drafted a new project with the title: Assessment of the cutaneous immune response during Trichophyton rubrum infection using an experimental mouse model. A significant progress was made in this project: I established an in vivo skin infection model with the anthropophilic dermatophyte T. rubrum, I established a single cell isolation protocol for flow cytometry of mouse skin, investigated the binding pattern of different C-type lectin receptors to T. rubrum conidia and generated an antibody against human MelLec. Thus, the basis for an independent research project was made.
Projektbezogene Publikationen (Auswahl)
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Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLoS One. 2017 Oct 12;12(10):e0184438
Mailänder-Sánchez, Daniela; Braunsdorf, Christina; Grumaz, Christian; Müller, Christoph; Lorenz, Stefan; Stevens, Philip; Wagener, Jeanette; Hebecker, Betty; Hube, Bernhard; Bracher, Franz; Sohn, Kai & Schaller, Martin
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Candida albicans-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers. MBio. 2018 Jun 5;9(3)
Allert, Stefanie; Förster, Toni M.; Svensson, Carl-Magnus; Richardson, Jonathan P.; Pawlik, Tony; Hebecker, Betty; Rudolphi, Sven; Juraschitz, Marc; Schaller, Martin; Blagojevic, Mariana; Morschhäuser, Joachim; Figge, Marc Thilo; Jacobsen, Ilse D.; Naglik, Julian R.; Kasper, Lydia; Mogavero, Selene & Hube, Bernhard
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Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus. Nature. 2018 Mar 15;555(7696):382-386
Stappers, Mark H. T.; Clark, Alexandra E.; Aimanianda, Vishukumar; Bidula, Stefan; Reid, Delyth M.; Asamaphan, Patawee; Hardison, Sarah E.; Dambuza, Ivy M.; Valsecchi, Isabel; Kerscher, Bernhard; Plato, Anthony; Wallace, Carol A.; Yuecel, Raif; Hebecker, Betty; da Glória Teixeira Sousa, Maria; Cunha, Cristina; Liu, Yan; Feizi, Ten; Brakhage, Axel A.; ... & Brown, Gordon D.
