Functional regulation of the mitochondrial presequence translocation complex (P12)

• Subject Area: Biochemistry
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 264061860

Over half of the proteins of a eukaryotic cell have to cross at least one membrane to reach their designated localization. In virtually all cellular membranes protein translocation machineries have been identified that either transport proteins across a membrane or facilitate their insertion into a particular membrane. At the heart of many of these translocation machineries protein conducting pores have been found that mediate import, export and membrane insertion. This project focuses on the molecular characterization of two protein conducting pores within the TIM23 and the Hrd1 complexes, that cover all three mentioned protein transport pathways.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1190: Compartmental Gates and Contact Sites in Cells
• Major Instrumentation: Patch-clamp system Port-a-Patch
• Instrumentation Group: 3590 Sonstige Geräte für Gewebe- und Zelluntersuchung
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Michael Meinecke