Role of soluble interleukin-6 receptor in liver damage and regeneration (A15)

• Subject Area: Immunology
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 190586431

Interleukin (IL)-6 trans-signalling via the soluble IL-6 receptor (sIL-6R) controls liver regeneration after partial hepatectomy. Own developments in synthetic cytokine biology allow for the first time the complementary use of loss-of-function and gain-of-function mouse models to clear which IL-6 target cells mediate liver regeneration after partial hepatectomy.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 974: Communication and System Relevance in Liver Injury and Regeneration
• Applicant Institution: Heinrich-Heine-Universität Düsseldorf
• Project Head: Professor Dr. Jürgen Scheller