DNA modifications in the evolution of hematopoietic neoplasms (A01)

• Subject Area: Biochemistry ; Hematology, Oncology ; Human Genetics ; Cell Biology
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 278529602

The aim of the project is to study the role and regulation of changes in DNA modifications and gene expression, using long-term in vitro cultured patient derived xenograft acute myeloid leukemia cells with and without selective pressure. We plan to look at genome-wide changes and at the conservation, variation and variance of patterns as a function of specific mutations in epigenetic modifiers (DNMT3A, TET2 and IDH1/2) and oncometabolite levels (2HG). The overall aim is to identify and counter epigenetic mechanisms that affect the response or resistance to therapy.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1243: Genetic and Epigenetic Evolution of Hematopoietic Neoplasms
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Heinrich Leonhardt