Evolution of transcription factor mutations in myeloid leukemias (A08)

• Subject Area: Hematology, Oncology ; Human Genetics
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 278529602

Hematopoietic transcription factors are critical for lineage fate and differentiation. The effect of transcription factor alterations will be analyzed in several murine and human models with focus on hematopoietic development, leukemogenesis and therapy resistance. In particular, the project will investigate the collaboration of GATA2 mutations or other candidates with the leukemic AML1-ETO fusion gene in the context of relapsed disease. Moreover, the analysis of epigenetic alterations of hematopoietic transcription factors and T-cell response during the disease course will put a spotlight on the interaction between leukemia cells and their microenvironment.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1243: Genetic and Epigenetic Evolution of Hematopoietic Neoplasms
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Privatdozent Dr. Philipp Greif; Professor Dr. Wolfgang Hiddemann