Dissecting the clonal hierarchy in MDS and involvement of the niche in the transition to secondary AML (A09)

• Subject Area: Hematology, Oncology ; Developmental Biology
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 278529602

Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis and frequent transformation to AML. How mutations in hematopoietic stem cells (HSC) alter proliferation, differentiation, and cell death, and the role of the bone marrow niche in disease progression is currently unresolved. We will now analyze MDS progression at single cell resolution, identify new pathways for drug intervention, quantify niche heterogeneity, and integrate our data into computational models to identify mechanisms of disease evolution.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1243: Genetic and Epigenetic Evolution of Hematopoietic Neoplasms
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professorin Dr. Katharina Simone Götze; Professor Dr. Robert A.J. Oostendorp