Genetic evolution of pre-germinal center B cell lymphomas in transgenic mice with the focus on Mantle Cell Lymphoma (A13)

• Subject Area: Hematology, Oncology ; Immunology
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 278529602

We will analyse cell intrinsic and extrinsic processes underlying MCL evolution. By chromatin- and transcriptional profiling as well as genome-wide functional screening we will identify cell-intrinsic signalling and regulatory networks driving stage-specific lymphoma evolution in mouse models. In parallel, we will characterize and functionalize cell/cell interactions of the lymphoma niche to evaluate the contribution of the microenvironment to lymphomagenesis. The insights gained into MCL biology through these studies will - together with our high-throughput combinatorial CRISPR dropout screens in human MCL - discover vulnerabilities for therapeutic targeting.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1243: Genetic and Epigenetic Evolution of Hematopoietic Neoplasms
• Applicant Institution: Ludwig-Maximilians-Universität München
• Co-Applicant Institution: Helmholtz Zentrum München; Deutsches Forschungszentrum für Gesundheit und Umwelt; Technische Universität München (TUM)
• Project Heads: Professor Dr. Roland Rad; Privatdozentin Dr. Ursula Zimber-Strobl