Neue Mechanismen des Primären Hyperaldosteronismus

• Antragsteller: Professor Dr. Felix Beuschlein
• Fachliche Zuordnung: Endokrinologie, Diabetologie, Metabolismus
• Förderung: Förderung von 2016 bis 2019
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 290424591

• Erstellungsjahr: 2019

Zusammenfassung der Projektergebnisse

The overall objective of this project had been the elucidation of unidentified factors which may drive excessive aldosterone production. 1) We have demonstrated that autoantibodies exist in patients with PA which activate the AT1R and are associated with inappropriate aldosterone production in patients with elevated AT1R‐Ab levels. Therefore, AT1R‐Abs may contribute to the pathophysiology of PA in a subset of patients. 2) We show that patients with macroprolactinomas are present at a higher than expected incidence in patients with PA and that prolactin stimulates aldosterone synthase gene expression and aldosterone production in human adrenocortical cells.

Projektbezogene Publikationen (Auswahl)

• Co‐existing prolactinoma and primary aldosteronism ‐ is there a pathophysiological link? J Clin Endocrinol Metab. 2015;100:E1262‐E1269
  Williams TA, Dietz AS, Theodoropoulou M, Riester A, Fischer E, Burrello J, Treitl M, Geyer L, Veglio F, Bidlingmaier M, Schopohl J, Beuschlein F, Mulatero P, Reincke M
  
• Prolactinoma and primary aldosteronism: is there a causal link? 17th European Congress of Endocrinology 2015 (ECE 2015), Dublin, Ireland
  Williams TA, Dietz A, Beuschlein F, Mulatero P, Reincke M
  
• Prolactinoma and primary aldosteronism: is there a causal link? German Society of Endocrinology (DGE 2015), Lübeck, Germany
  Williams TA, Dietz A, Beuschlein F, Mulatero P, Reincke M
  
• Immunohistopathology and Steroid Profiles Associated With Biochemical Outcomes After Adrenalectomy for Unilateral Primary Aldosteronism. Hypertension. 2018 Sep;72(3):650‐657
  Meyer LS, Wang X, Sušnik E, Burrello J, Burrello A, Castellano I, Eisenhofer G, Fallo F, Kline GA, Knösel T, Kocjan T, Lenders JWM, Mulatero P, Naruse M, Nishikawa T, Peitzsch M, Rump LC, Beuschlein F, Hahner S, Gomez‐Sanchez CE, Reincke M, Williams TA
  
• Diverse responses of autoantibodies to the angiotensin II type 1 receptor in primary aldosteronism. Hypertension 2019;74(4):784‐792
  Williams TA, Jaquin D, Burrello J, Philippe A, Yang Y, Rank P, Nirschl N, Sturm L, Hübener C, Dragun D, Bidlingmaier M, Beuschlein F, Reincke M