The cold shock protein YB-1 (Y-box protein-1) in chronic T cell responses and systemic lupus erythematosus (SLE)
Final Report Abstract
Understanding how deregulated apoptosis - not only of SLE T-cells - can be manipulated is a fundamental question in immunology. Within the project we could demonstrate for the first time that SLE T-cells can hardly upregulate the cold shock protein YB-1. Expression was a prerequisite for survival and has directed us to generate a model that explains chronicity of the SLE pathology. We identified PUMA for induction of apoptosis in the absence of YB-1 and the kinase Akt to be responsible for YB-1 mediated resistance against activation induced cell death. The results demonstrate that reduced YB-1 accumulation is a novel signatory function of SLE T-cells. Our results stress also the point that SLE cells show viability when YB-1 is re-expressed and, thus, can be manipulated by impinging on YB-1 signal transduction.
Publications
-
RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells and T-ALL blasts. . Cell Death Differ. 2017;24(2):371-383
Gieseler-Halbach, Steffi; Meltendorf, Stefan; Pierau, Mandy; Weinert, Soenke; Heidel, Florian H.; Fischer, Thomas; Handschuh, Juliane; Braun-Dullaeus, Ruediger C.; Schrappe, Martin; Lindquist, Jonathan A.; Mertens, Peter R.; Thomas, Ulrich & Brunner-Weinz
-
Inflammatory cell infiltration and resolution of kidney inflammation is orchestrated by the cold-shock protein Y-box binding protein-1. Kidney Int. 2017;92(5):1157-1177
Bernhardt, Anja; Fehr, Alexander; Brandt, Sabine; Jerchel, Saskia; Ballhause, Tobias M.; Philipsen, Lars; Stolze, Saskia; Geffers, Robert; Weng, Honglei; Fischer, Klaus-Dieter; Isermann, Berend; Brunner-Weinzierl, Monika C.; Batra, Arvind; Siegmund, Britta; Zhu, Cheng; Lindquist, Jonathan A. & Mertens, Peter R.
-
Failure of upregulation of the cold shock Y-box protein-1 in effector T-cells of systemic lupus erythematosus patients averts cell survival. Arthritis & Rheumatol. 2020
Meltendorf, Stefan; Fu, Hang; Pierau, Mandy; Lindquist, Jonathan A.; Finzel, Stephanie; Mertens, Peter R.; Gieseler‐Halbach, Steffi; Ambach, Andreas; Thomas, Ulrich; Lingel, Holger; Voll, Reinhard E. & Brunner‐Weinzierl, Monika C.
