Mechanismen der protektiven Wirkung von Darbepoetin bei biliärer Fibrose

Subject Area General and Visceral Surgery

Term from 2006 to 2015

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 29528568

Final Report Year 2009

Final Report Abstract

No abstract available

Attenuation of inflammation and apoptosis by pre- and posttreatment of darbepoetin-alpha in acute liver failure of mice. Am J Pathol. 2007;170:1954-63
Le Minh K, Klemm K, Abshagen K, Eipel C, Menger MD, Vollmar B
Darbepoetin-alpha does not promote microvascular thrombus formation in mice: role of eNOS-dependent protection through platelet and endothelial cell deactivation. Arterioscler Thromb Vasc Biol. 2007;27:1191-8
Lindenblatt N, Menger MD, Klar E, Vollmar B
Erythropoietin improves functional and histological recovery of traumatized skeletal muscle tissue. J Orthop Res. 2008;26:1618-26
Rotter R, Menshykova M, Winkler T, Matziolis G, Stratos I, Schoen M, Bittorf T, Mittlmeier T, Vollmar B
Multiple doses of erythropoietin impair liver regeneration by increasing TNF-alpha, the Bax to Bcl-xL ratio and apoptotic cell death. PLoS One. 2008;3:e3924
Klemm K, Eipel C, Cantré D, Abshagen K, Menger MD, Vollmar B
Effects of erythropoietin in skin wound healing are dose related. FASEB J. 2009;23:3049-58
Sorg H, Krueger C, Schulz T, Menger MD, Schmitz F, Vollmar B
Erythropoietin reduces necrosis in critically ischemic myocutaneous tissue by protecting nutritive perfusion in a dose-dependent manner. Surgery. 2009;145:372-83
Harder Y, Amon M, Schramm R, Contaldo C, Metzkow E, Matzen A, Rücker M, Vollmar B, Menger MD