KFO 167:  Regulation of Apoptosis and its Deregulation in Disease

• Subject Area: Medicine
• Term: from 2006 to 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 29548890

• Final Report Year: 2015

No abstract available

Publications

• Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease. Gastroenterology, Vol. 132. 2007, Issue 4, pp. 1465-1475.
  Lechel, André; Holstege, Henne; Begus, Yvonne; Schienke, Andrea; Kamino, Kenji; Lehmann, Ulrich; Kubicka, Stefan; Schirmacher, Peter; Jonkers, Jos & Rudolph, K. Lenhard
  
• Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation. Oncogene, Vol. 26. 2007, pp. 6536–6545.
  Azoitei, N.; Brey, A.; Busch, T.; Fulda, S.; Adler, G. & Seufferlein, T.
  
• DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin. Molecular Biology of the Cell, Vol. 19. 2008, No. 8, pp. 3179-3613.
  Friesen, Claudia; Uhl, Miriam; Pannicke, Ulrich; Schwarz, Klaus; Miltner, Erich & Debatin, Klaus-Michael
  
• Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner. Carcinogenesis, Vol. 29. 2008, Issue 3, pp. 519–527.
  Gatz, Susanne Andrea; Keimling, Marlen; Baumann, Cindy; Dörk, Thilo; Debatin, Klaus-Michael; Fulda, Simone & Wiesmüller, Lisa
  
• Identification of a novel pro-apopotic function of NF-kappaB in the DNA damage response. Journal of Cellular and Molecular Medicine, Vol. 13. 2009, Issue 10, pp. 4239-4256.
  Karl, Sabine; Pritschow, Yvonne; Volcic, Meta; Häcker, Sabine; Baumann, Bernd; Wiesmüller, Lisa; Debatin, Klaus‐Michael & Fulda, Simone
  
• The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses. Journal of Clinical Investigation, Vol. 119. 2009, Issue 10, pp. 2965–2975.
  Arhel, Nathalie; Lehmann, Martin; Clauß, Karen; Nienhaus, G. Ulrich; Piguet, Vincent & Kirchhoff, Frank
  
• Refractory chronic lymphocytic leukemia--new therapeutic strategies. Oncotarget, Vol.1. 2010, Issue 7, pp. 472-482.
  Schnaiter A., Stilgenbauer S.
  
• Targeting mitochondria for cancer therapy. Nature Reviews Drug Discovery, Vol. 9. 2010, Issue 6, pp. 447–464.
  Hockenbery, David M.
  
• Diversity of human leukemia xenograft mouse models: implications for disease biology. Cancer Research, Vol. 71. 2011, Issue 23, pp. 7141-7144.
  Meyer, Lüder Hinrich & Debatin, Klaus-Michael
  
• Identification of a novel proapoptotic role of NF-kappaB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells. Oncogene, Vol. 31. 2012, Issue 11, pp. 1468–1474.
  Jennewein, C.; Karl, S.; Baumann, B.; Micheau, O.; Debatin, K.-M. & Fulda, S.
  
• Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction. Nature Cell Biology, Vol. 14. 2012, Issue 1, pp. 73–79.
  Sperka, Tobias; Song, Zhangfa; Morita, Yohei; Nalapareddy, Kodandaramireddy; Guachalla, Luis Miguel; Lechel, André; Begus-Nahrmann, Yvonne; Burkhalter, Martin D.; Mach, Monika; Schlaudraff, Falk; Liss, Birgit; Ju, Zhenyu; Speicher, Michael R. & Rudolph, K. Lenhard
  
• Anti-CD33-antibodies labelled with the alpha-emitter Bismuth-213 kill CD33-positive acute myeloid leukaemia cells specifically by activation of caspases and break radio- and chemoresistance by inhibition of the anti-apoptotic proteins X-linked inhibitor of apoptosis protein and B-cell lymphoma-extra large. European Journal of Cancer, Vol. 49. 2013, Issue 11, pp. 2542-2554.
  Friesen, Claudia; Roscher, Mareike; Hormann, Inis; Leib, Oliver; Marx, Sebastian; Moreno, Josue & Miltner, Erich
  
• Sustained, neuron-specific IKK/NF-kappaB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging. Molecular Neurodegeneration, Vol. 8. 2013, Article number: 40.
  Maqbool, Ayesha; Lattke, Michael; Wirth, Thomas & Baumann, Bernd
  
• Fluorescence-based recombination assay for sensitive and specific detection of genotoxic carcinogens in human cells. Archives of Toxicology, Vol. 88. 2014, pp. 1141–1159.
  Ireno, Ivanildce C.; Baumann, Cindy; Stöber, Regina; Hengstler, Jan G. & Wiesmüller, Lisa
  
• Viremic long-term nonprogressive HIV-1 infection is not associated with abnormalities in known Nef functions. Retrovirology, Vol. 11. 2014, Article number: 13.
  Heigele, Anke; Camerini, David; van’t Wout, Angélique B & Kirchhoff, Frank
  
• Targeting inhibitor of apoptosis proteins by Smac mimetic elicits cell death in poor prognostic subgroups of chronic lymphocytic leukemia. International Journal of Cancer, Vol. 137. 2015, Issue 12, pp. 2959-2970.
  Opel, Daniela; Schnaiter, Andrea; Dodier, Dagmar; Jovanovic, Marjana; Gerhardinger, Andreas; Idler, Irina; Mertens, Daniel; Bullinger, Lars; Stilgenbauer, Stephan & Fulda, Simone
  
• Intrinsic and chemo-sensitizing ctivity of Smac-mimetics on high-risk childhood acute lymphoblastic leukemia. Cell Death & Disease, Vol. 7. 2016, e2052.
  Schirmer, M; Trentin, L; Queudeville, M; Seyfried, F; Demir, S; Tausch, E; Stilgenbauer, S; Eckhoff, S M; Meyer, L H & Debatin, K-M