Astrocyte-specific function of OTUB1 in experimental autoimmune encephalomyelitis

• Applicant: Dr. Xu Wang, Ph.D.
• Subject Area: Molecular and Cellular Neurology and Neuropathology ; Immunology
• Term: from 2016 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 302097871

• Final Report Year: 2019

Final Report Abstract

We have completed the project successfully. The key findings of this project are: OTUB1 expression is induced in astrocytes of MS patients and EAE mice. - OTUB1 ablation in astrocytes aggravates EAE. - OTUB1 suppresses IFN-γ-induced chemokine production by astrocytes. - OTUB1 inhibits IFN-γ-induced JAK-STAT1 signaling by deubiquitinating and stabilizing the inhibitor SOCS1.

Publications

• Astrocytes in multiple sclerosis and experimental autoimmune encephalomyelitis: Star-shaped cells illuminating the darkness of CNS autoimmunity. Brain Behav Immun. 2019 May 21
  Yi W, Schlüter D, Wang X
  (See online at https://doi.org/10.1016/j.bbi.2019.05.029)
• OTUB1 inhibits CNS autoimmunity by preventing IFN-γ-induced hyperactivation of astrocytes. EMBO J. 2019 May 15;38(10)
  Wang X, Mulas F, Yi W, Brunn A, Nishanth G, Just S, Waisman A, Brück W, Deckert M, Schlüter D
  (See online at https://doi.org/10.15252/embj.2018100947)