The role of the Alzheimer related Amyloid Precursor Protein Gene Family in the Developing and Adult Nervous System

Antragstellerin Professorin Dr. Ulrike Müller

Fachliche Zuordnung Molekulare Biologie und Physiologie von Nerven- und Gliazellen

Förderung Förderung von 2006 bis 2010

Projektkennung Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 30636411

Erstellungsjahr 2010

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

(2008) Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway. Eur J Neurosci 28: 871-882
Gakhar-Koppole N, Hundeshagen P, Mandl C, Weyer SW, Allinquant B, Müller U, Ciccolini F
(2008) Embryonic stem cell-derived neurons as a cellular system to study gene function: lack of amyloid precursor proteins APP and APLP2 leads to defective synaptic transmission. Stem Cells 26: 2153-2163
Schrenk-Siemens K, Perez-Alcala S, Richter J, Lacroix E, Rahuel J, Korte M, Müller U, Barde YA, Bibel M
(2010) Generation of conditional null alleles for APP and APLP2. Genesis 48: 200-206
Mallm JP, Tschape JA, Hick M, Filippov MA, Müller UC
(2010) Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of the amyloid precursor protein in neuronal differentiation. Stem Cells 28: 399-406
Bergmans BA, Shariati SA, Habets RL, Verstreken P, Schoonjans L, Müller U, Dotti CG, De Strooper B