Glucosylierung durch clostridiale Zytotoxine: Enzymaktivität, Substraterkennung und Auffindung kleinmolekularer Inhibitoren

• Applicant: Professor Dr. Klaus Aktories, since 7/2008
• Subject Area: Pharmacology
• Term: from 2006 to 2010
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 30984551

• Final Report Year: 2010

Final Report Abstract

No abstract available

Publications

• 2006. Exchange of a single amino acid switches the substrate properties of RhoA and RhoD towards glucosylating and transglutaminating toxins. J. Biol. Chem. 281:19527-19535
  Jank, T., Pack, U., Giesemann, T., Schmidt, G., and Aktories, K.
  
• 2007. Clostridium difficile glucosyltransferase toxin B - essential amino acids for substrate-binding. J. Biol. Chem. 282:35222-35231
  Jank, T., Giesemann, T., and Aktories, K.
  
• 2007. Rho-glucosylating Clostridium difficile toxins A and B: New insights into structure and function. Glycobiology 17:15R-22R
  Jank, T., Giesemann, T., and Aktories, K.
  
• 2008. Conformational changes and reaction of clostridial glycosylating toxins. J. Mol. Biol. 377:1346-1356
  Ziegler, M.O., Jank, T., Aktories, K., and Schulz, G.E.
  
• 2008. Human alpha-defensins inhibit Clostridium difficile toxin B. Gastroenterology 134:2049-2058
  Giesemann, T., Guttenberg, G., and Aktories, K.
  
• 2008. Inhibition of the glucosyltransferase activity of clostridial Rho/Ras-glucosylating toxins by castanospermine. FEBS Lett. 582:2277-2282
  Jank, T., Ziegler, M.O., Schulz, G.E., and Aktories, K.
  
• 2008. Structure and mode of action of clostridial glucosylating toxins: the ABCD model. Trends Microbiol. 16:222-229
  Jank, T., and Aktories, K.