Axonal mRNP alterations in spinal muscular atrophy

• Applicants: Dr. Michael Briese; Professor Dr. Michael A. Sendtner
• Subject Area: General Genetics and Functional Genome Biology
• Term: from 2016 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 313233411

• Final Report Year: 2024

No abstract available

Publications

• hnRNP R and its main interactor, the noncoding RNA 7SK, coregulate the axonal transcriptome of motoneurons. Proceedings of the National Academy of Sciences, 115(12).
  Briese, Michael; Saal-Bauernschubert, Lena; Ji, Changhe; Moradi, Mehri; Ghanawi, Hanaa; Uhl, Michael; Appenzeller, Silke; Backofen, Rolf & Sendtner, Michael
  
• Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function. Acta Neuropathologica Communications, 8(1).
  Briese, Michael; Saal-Bauernschubert, Lena; Lüningschrör, Patrick; Moradi, Mehri; Dombert, Benjamin; Surrey, Verena; Appenzeller, Silke; Deng, Chunchu; Jablonka, Sibylle & Sendtner, Michael
  
• Interaction of 7SK with the Smn complex modulates snRNP production. Nature Communications, 12(1).
  Ji, Changhe; Bader, Jakob; Ramanathan, Pradhipa; Hennlein, Luisa; Meissner, Felix; Jablonka, Sibylle; Mann, Matthias; Fischer, Utz; Sendtner, Michael & Briese, Michael
  
• Keeping the balance: The noncoding RNA 7SK as a master regulator for neuron development and function. BioEssays, 43(8).
  Briese, Michael & Sendtner, Michael
  
• Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin. Nucleic Acids Research, 49(21), 12284-12305.
  Ghanawi, Hanaa; Hennlein, Luisa; Zare, Abdolhossein; Bader, Jakob; Salehi, Saeede; Hornburg, Daniel; Ji, Changhe; Sivadasan, Rajeeve; Drepper, Carsten; Meissner, Felix; Mann, Matthias; Jablonka, Sibylle; Briese, Michael & Sendtner, Michael
  
• hnRNP R negatively regulates transcription by modulating the association of P‐TEFb with 7SK and BRD4. EMBO reports, 23(9).
  Ji, Changhe; Deng, Chunchu; Antor, Katharina; Bischler, Thorsten; Schneider, Cornelius; Fischer, Utz; Sendtner, Michael & Briese, Michael
  
• Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr. Nature Communications, 14(1).
  Salehi, Saeede; Zare, Abdolhossein; Prezza, Gianluca; Bader, Jakob; Schneider, Cornelius; Fischer, Utz; Meissner, Felix; Mann, Matthias; Briese, Michael & Sendtner, Michael
  
• Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy. Journal of Cell Biology, 222(3).
  Hennlein, Luisa; Ghanawi, Hanaa; Gerstner, Florian; Palominos García, Eduardo; Yildirim, Ezgi; Saal-Bauernschubert, Lena; Moradi, Mehri; Deng, Chunchu; Klein, Teresa; Appenzeller, Silke; Sauer, Markus; Briese, Michael; Simon, Christian; Sendtner, Michael & Jablonka, Sibylle
  
• hnRNP R regulates mitochondrial movement and membrane potential in axons of motoneurons. Neurobiology of Disease, 193(c(2024, 4)), 106454.
  Dithmar, Sophia; Zare, Abdolhossein; Salehi, Saeede; Briese, Michael & Sendtner, Michael