Investigation of the molecular mechanisms and interplay of TTP-mediated mRNA decay and translational repression using structural and biochemical tools

• Applicant: Professorin Sutapa Chakrabarti, Ph.D.
• Subject Area: General Genetics and Functional Genome Biology ; Biochemistry ; Structural Biology
• Term: from 2016 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 313425078

No abstract available

Publications

• A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner. Nucleic Acids Research, 46(5), 2648-2659.
  Gowravaram, Manjeera; Bonneau, Fabien; Kanaan, Joanne; Maciej, Vincent D; Fiorini, Francesca; Raj, Saurabh; Croquette, Vincent; Le Hir, Hervé & Chakrabarti, Sutapa
  
• Intrinsically disordered regions of tristetraprolin and DCP2 directly interact to mediate decay of ARE-mRNA. Nucleic Acids Research, 50(18), 10665-10679.
  Maciej, Vincent D; Mateva, Nevena; Schwarz, Juliane; Dittmers, Theresa; Mallick, Megha; Urlaub, Henning & Chakrabarti, Sutapa
  
• Modulation of RNA-binding properties of the RNA helicase UPF1 by its activator UPF2. RNA, 29(2), 178-187.
  Xue, Guangpu; Maciej, Vincent D.; Machado de Amorim, Alexandrina; Pak, Melis; Jayachandran, Uma & Chakrabarti, Sutapa