Allosterie und Proteostase des regulierten Aktomyosinsystems in humanen Herzmuskelzellen

• Antragsteller: Professor Dr. Dietmar J. Manstein
• Fachliche Zuordnung: Biochemie ; Kardiologie, Angiologie ; Strukturbiologie
• Förderung: Förderung von 2016 bis 2020
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 314376469

• Erstellungsjahr: 2021

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (2018) Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton. Curr. Biol. 28, 2331-2337 e2335
  Meiring, J. C. M., Bryce, N. S., Wang, Y., Taft, M. H., Manstein, D. J., Liu Lau, S., Stear, J., Hardeman, E. C., and Gunning, P. W.
  
• (2017) Tropomyosin Isoforms Specify Functionally Distinct Actin Filament Populations in vitro. Curr. Biol. 27, 705-713
  Gateva, G., Kremneva, E., Reindl, T., Kotila, T., Kogan, K., Gressin, L., Gunning, P. W., Manstein, D. J., Michelot, A., and Lappalainen, P.
  
• (2018) Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia. Nat. Commun. 9, 4250
  Latham, S. L., Ehmke, N., Reinke, P. Y. A., Taft, M. H., Eicke, D., Reindl, T., Stenzel, W., Lyons, M. J., Friez, M. J., Lee, J. A., Hecker, R., Fruhwald, M. C., Becker, K., Neuhann, T. M., Horn, D., Schrock, E., Niehaus, I., Sarnow, K., Grutzmann, K., Gawehn, L., Klink, B., Rump, A., Chaponnier, C., Figueiredo, C., Knofler, R., Manstein, D. J., and Di Donato, N.
  
• (2019) Phenamacril is a reversible and noncompetitive inhibitor of Fusarium class I myosin. J. Biol. Chem. 294, 1328-1337
  Wollenberg, R. D., Taft, M. H., Giese, S., Thiel, C., Balazs, Z., Giese, H., Manstein, D.J. , and Sondergaard, T. E.
  
• (2020) Actintropomyosin distribution in non-muscle cells. J. Muscle Res. Cell Motil. 41, 11-22
  Manstein, D. J., Meiring, J. C. M., Hardeman, E. C., and Gunning, P. W.
  
• (2020) Enhanced super-resolution microscopy by combined Airyscan and Quantum-Dot-Triexciton Imaging
  Hennig, S., and Manstein, D. J.
  
• (2020) Mechanochemical properties of human myosin 1C are modulated by isoform-specific differences in the N-terminal extension. J Biol Chem
  Giese, S., Reindl, T., Reinke, P. Y. A., Zattelman, L., Fedorov, R., Henn, A., Taft, M. H., and Manstein, D. J.
  
• (2020) Myosin-18B Regulates Higher-Order Organization of the Cardiac Sarcomere through Thin Filament Cross-Linking and Thick Filament Dynamics. Cell Rep. 32, 108090
  Latham, S. L., Weiss, N., Schwanke, K., Thiel, C., Croucher, D. R., Zweigerdt, R., Manstein, D. J., and Taft, M. H.
  
• (2020) Small Molecule Effectors of Myosin Function. Adv Exp Med Biol 1239, 61-84
  Manstein, D. J., and Preller, M.
  
• (2020) Undefeated-Changing the phenamacril scaffold is not enough to beat resistant Fusarium. PLoS One 15, e0235568
  Wollenberg, R. D., Donau, S. S., Taft, M. H., Balazs, Z., Giese, S., Thiel, C., Sorensen, J. L., Nielsen, T. T., Giese, H., Manstein, D. J., Wimmer, R., and Sondergaard, T. E.
  
• (2021) Muscle myosin performance measured with a synthetic nanomachine reveals a class-specific Ca2+-sensitivity of the frog myosin II isoform. J Physiol.
  Pertici, I., Bianchi, G., Bongini, L., Cojoc, D., Taft, M.H., Manstein, D.J., Lombardi, V., Bianco, P.