Allostery and Proteostasis of Regulated Actomyosin Systems in Human Cardiomyocytes

• Applicant: Professor Dr. Dietmar J. Manstein
• Subject Area: Biochemistry ; Cardiology, Angiology ; Structural Biology
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314376469

• Final Report Year: 2021

No abstract available

Publications

• (2017) Tropomyosin Isoforms Specify Functionally Distinct Actin Filament Populations in vitro. Curr. Biol. 27, 705-713
  Gateva, Gergana; Kremneva, Elena; Reindl, Theresia; Kotila, Tommi; Kogan, Konstantin; Gressin, Laurène; Gunning, Peter W.; Manstein, Dietmar J.; Michelot, Alphée & Lappalainen, Pekka
  
• (2018) Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton. Curr. Biol. 28, 2331-2337 e2335
  Meiring, Joyce C.M.; Bryce, Nicole S.; Wang, Yao; Taft, Manuel H.; Manstein, Dietmar J.; Liu Lau, Sydney; Stear, Jeffrey; Hardeman, Edna C. & Gunning, Peter W.
  
• (2018) Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia. Nat. Commun. 9, 4250
  Latham, Sharissa L.; Ehmke, Nadja; Reinke, Patrick Y. A.; Taft, Manuel H.; Eicke, Dorothee; Reindl, Theresia; Stenzel, Werner; Lyons, Michael J.; Friez, Michael J.; Lee, Jennifer A.; Hecker, Ramona; Frühwald, Michael C.; Becker, Kerstin; Neuhann, Teresa M.; Horn, Denise; Schrock, Evelin; Niehaus, Indra; Sarnow, Katharina; Grützmann, Konrad; ... & Di Donato, Nataliya
  
• (2019) Phenamacril is a reversible and noncompetitive inhibitor of Fusarium class I myosin. J. Biol. Chem. 294, 1328-1337
  Wollenberg, Rasmus D.; Taft, Manuel H.; Giese, Sven; Thiel, Claudia; Balázs, Zoltán; Giese, Henriette; Manstein, Dietmar J. & Sondergaard, Teis E.
  
• (2020) Actintropomyosin distribution in non-muscle cells. J. Muscle Res. Cell Motil. 41, 11-22
  Manstein, Dietmar J.; Meiring, J. C. M.; Hardeman, E. C. & Gunning, Peter W.
  
• (2020) Enhanced super-resolution microscopy by combined Airyscan and Quantum-Dot-Triexciton Imaging
  Hennig, Simon & Manstein, Dietmar J.
  
• (2020) Myosin-18B Regulates Higher-Order Organization of the Cardiac Sarcomere through Thin Filament Cross-Linking and Thick Filament Dynamics. Cell Rep. 32, 108090
  Latham, Sharissa L.; Weiß, Nadine; Schwanke, Kristin; Thiel, Claudia; Croucher, David R.; Zweigerdt, Robert; Manstein, Dietmar J. & Taft, Manuel H.
  
• (2020) Small Molecule Effectors of Myosin Function. Adv Exp Med Biol 1239, 61-84
  Manstein, Dietmar J. & Preller, Matthias
  
• (2020) Undefeated-Changing the phenamacril scaffold is not enough to beat resistant Fusarium. PLoS One 15, e0235568
  Wollenberg, Rasmus D.; Donau, Søren S.; Taft, Manuel H.; Balázs, Zoltan; Giese, Sven; Thiel, Claudia; Sørensen, Jens L.; Nielsen, Thorbjørn T.; Giese, Henriette; Manstein, Dietmar J.; Wimmer, Reinhard & Sondergaard, Teis E.
  
• (2020) Mechanochemical properties of human myosin 1C are modulated by isoform-specific differences in the N-terminal extension. J Biol Chem
  Giese, Sven; Reindl, Theresia; Reinke, Patrick Y.A.; Zattelman, Lilach; Fedorov, Roman; Henn, Arnon; Taft, Manuel H. & Manstein, Dietmar J.
  
• (2021) Muscle myosin performance measured with a synthetic nanomachine reveals a class-specific Ca2+-sensitivity of the frog myosin II isoform. J Physiol.
  Pertici, Irene; Bianchi, Giulio; Bongini, Lorenzo; Cojoc, Dan; Taft, Manuel H.; Manstein, Dietmar J.; Lombardi, Vincenzo & Bianco, Pasquale