Right Ventricular (RV) function in Pulmonary Hypertension and impact of targeted interventions on RV-PA (Pulmonary Artery) coupling (B08)

• Subject Area: Pneumology, Thoracic Surgery
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 268555672

We established and validated methods to determine load-independent contractility of the right ventricle (RV). The RV has a remarkable reserve before progressing towards maladaptive dilatation (“point of uncoupling”). As a gold-standard technique to determine RV-contractility as well as RV-PA coupling, we established pressure/volume (PV)-loop assessments with varying RV-preload. During the following funding period we will further develop non-invasive means to measure RV function and to assess the direct impact of PH-specific on load-independent RV-function. Furthermore, issues related to right ventricular/left ventricular interdependency will be addressed in pre-clinical models within the CRC.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1213: Pulmonary Hypertension and Cor Pulmonale
• Applicant Institution: Justus-Liebig-Universität Gießen
• Project Heads: Professor Dr. Hossein Ardeschir Ghofrani; Professor Dr. Werner Seeger, until 6/2020; Privatdozent Dr. Khodr Tello