Neue WRC interagierende Rezeptoren zur Signaltransduktion von der Membran zum Aktin-Zytoskelett

• Antragsteller: Professor Dr. Sven Bogdan
• Fachliche Zuordnung: Entwicklungsbiologie
• Förderung: Förderung von 2016 bis 2021
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 316970849

• Erstellungsjahr: 2022

Zusammenfassung der Projektergebnisse

Changes in cell morphology and cell motility require the dynamic remodeling of the actin cytoskeleton. To study the dynamics and function of the actin cytoskeleton in vivo, we have established different genetically traceable Drosophila model systems that allow live-cell imaging combined with new advanced high-resolution microscopy techniques. Our data uncovered novel mechanisms but also new conserved molecules by which chemical or physical signals are transduced to the actin cytoskeleton to control directed single immune cell migration, but also collective cell migration during wound closure and organogenesis.

Projektbezogene Publikationen (Auswahl)

• (2017). Adherens Junctions on the Move-Membrane Trafficking of E-Cadherin. Cold Spring Harb Perspect Biol 9
  Brüser L, Bogdan S
  (Siehe online unter https://doi.org/10.1101/cshperspect.a029140)
• (2017). Molecular Control of Actin Dynamics In Vivo: Insights from Drosophila. Handbook of experimental pharmacology 235: 285-310
  Brüser L, Bogdan S.
  (Siehe online unter https://doi.org/10.1007/164_2016_33)
• (2018). Analysis of Cell Shape and Cell Migration of Drosophila Macrophages In Vivo. Methods Molecular Biology Vol. 1749, 978-1-4939
  Rüder M, Nagel BM, Bogdan S
  (Siehe online unter https://doi.org/10.1007/978-1-4939-7701-7_17)
• (2019). Transient localization of the Arp2/3 complex initiates neuronal dendrite branching in vivo. Development. Apr 4;146(7)
  Stuermer, T., Tatarnikova, A., Mueller, J., Schaffran, B., Cuntz, H., Zhang, Y., Nemetova, M., Bogdan, S., Small, V. and Tavosanis, G.
  (Siehe online unter https://doi.org/10.1242/dev.171397)
• (2021). CK1alpha protects WAVE from degradation to regulate cell shape and motility in the immune response. Journal of Cell Science 134
  Hirschhauser, A., M. van Cann, and Bogdan S.
  (Siehe online unter https://doi.org/10.1242/jcs.258891)
• (2021). Collective cell migration driven by filopodia - New insights from the social behavior of myotubes. Bioessays 43, e2100124
  Bischoff, M.C., and Bogdan, S.
  (Siehe online unter https://doi.org/10.1002/bies.202100124)
• (2021). Filopodia-based contact stimulation of cell migration drives tissue morphogenesis. Nature Communications 12:791
  Bischoff, M.C., S. Lieb, R. Renkawitz-Pohl, and S. Bogdan
  (Siehe online unter https://doi.org/10.1038/s41467-020-20362-2)
• (2022). Analysis of collective cell behavior in migrating testis myotubes in Drosophila. Methods Molecular Biology
  Bischoff, M.C., and S. Bogdan
  (Siehe online unter https://doi.org/10.1007/978-1-0716-2887-4_8)