Host and bacterial factors driving chronic Salmonella infections (A08)

• Subject Area: Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
• Term: from 2016 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 158989968

Chronic infections in humans caused by Salmonella enterica serovars cause major problems worldwide. Mechanisms that lead to persistence of Salmonella are incompletely understood. In this project we aim to identify the host and bacterial factors that lead to persistent infections with Salmonella. We focus on the role of host matrix metalloproteinase 10 and Salmonella pathogenicity island-1 effectors in persistence.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 900: Chronic Infections: Microbial Persistence and its Control
• Applicant Institution: Medizinische Hochschule Hannover
• Project Head: Professor Dr. Guntram Alexander Graßl