Role of IFN-lambda in host defense against respiratory virus infections

• Applicant: Professor Dr. Peter Stäheli
• Subject Area: Virology
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317170439

• Final Report Year: 2019

No abstract available

Publications

• Interferon-λ prevents influenza virus spread from the upper respiratory tract to the lungs and limits virus transmission. eLife 7: e33354 (2018)
  Klinkhammer, Jonas; Schnepf, Daniel; Ye, Liang; Schwaderlapp, Marilena; Gad, Hans Henrik; Hartmann, Rune; Garcin, Dominique; Mahlakõiv, Tanel & Staeheli, Peter
  
• (2016). Role of Interferon-λ in the spread of influenza viruses from the upper respiratory tract to the lungs and in virus transmission among mice. Doktorarbeit, Medizinische Fakultät, Universität Freiburg
  Klinkhammer, J.
  
• (2019). Interferon-lambda: a cytokine controlling innate and adaptive antiviral mucosal immunity. Doktorarbeit, Fakultät für Biologie, Universität Freiburg
  Ye, L.
  
• (2019). Interferon-λ: a cytokine orchestrating innate and adaptive mucosal immune responses. Doktorarbeit, Fakultät für Biologie, Universität Freiburg
  Schnepf, D.
  
• Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin. Nature Immunology 20: 593-601 (2019)
  Ye, Liang; Schnepf, Daniel; Becker, Jan; Ebert, Karolina; Tanriver, Yakup; Bernasconi, Valentina; Gad, Hans Henrik; Hartmann, Rune; Lycke, Nils & Staeheli, Peter
  
• Interferon-λ orchestrates innate and adaptive mucosal immune responses. Nature Reviews Immunology 19: 614-625 (2019)
  Ye, Liang; Schnepf, Daniel & Staeheli, Peter
  
• Type I and type III interferons differ in their adjuvant activities for influenza vaccines. J. Virology 93: e01262 (2019)
  Ye, Liang; Ohnemus, Annette; Ong, Li Ching; Gad, Hans Henrik; Hartmann, Rune; Lycke, Nils & Staeheli, Peter